Chen SH |
------>authors3_c= ------>paper_class1=1 ------>Impact_Factor=2.081 ------>paper_class3=2 ------>paper_class2=1 ------>vol=11 ------>confirm_bywho=hsuan ------>insert_bywho=lhtsai ------>Jurnal_Rank=58.2 ------>authors4_c= ------>comm_author= ------>patent_EDate=None ------>authors5_c= ------>publish_day=28 ------>paper_class2Letter=None ------>page2=3750 ------>medlineContent= ------>unit=E0105 ------>insert_date=20041124 ------>iam=4 ------>update_date=None ------>author=??? ------>change_event=4 ------>ISSN=1007-9327 ------>authors_c= ------>score=500 ------>journal_name=World Journal of Gastroenterology ------>paper_name=Protective effects of Ginkgo biloba extract on the ethanol-induced gastric ulcer in rats. ------>confirm_date=20091111 ------>tch_id=059001 ------>pmid=15968732 ------>page1=3746 ------>fullAbstract=AIM: To evaluate the preventive effect of Ginkgo biloba extract (GbE) on ethanol-induced gastric mucosal injuries in rats. METHODS: Female Wistar albino rats were used for the studies. We randomly divided the rats for each study into five subgroups: normal control, experimental control, and three experimental groups. The gastric ulcers were induced by instilling 1 mL 50% ethanol into the stomach. We gave GbE 8.75, 17.5, 26.25 mg/kg intravenously to the experimental groups respectively 30 min prior to the ulcerative challenge. We removed the stomachs 45 min later. The gastric ulcers, gastric mucus and the content of non-protein sulfhydryl groups (NP-SH), malondialdehyde (MDA), c-Jun kinase (JNK) activity in gastric mucosa were evaluated. The amount of gastric juice and its acidity were also measured. RESULTS: The findings of our study are as follows: (1) GbE pretreatment was found to provide a dose-dependent protection against the ethanol-induced gastric ulcers in rats; (2) the GbE pretreatment afforded a dose-dependent inhibition of ethanol-induced depletion of stomach wall mucus, NP-SH contents and increase in the lipid peroxidation (increase MDA) in gastric tissue; (3) gastric ulcer induced by ethanol produced an increase in JNK activity in gastric mucosa which also significantly inhibited by pretreatment with GbE; and (4) GbE alone had no inhibitory effect on gastric secretion in pylorus-ligated rats. CONCLUSION: The finding of this study showed that GbE significantly inhibited the ethanol-induced gastric lesions in rats. We suggest that the preventive effect of GbE may be mediated through: (1) inhibition of lipid peroxidation; (2) preservation of gastric mucus and NP-SH; and (3) blockade of cell apoptosis. ------>tmu_sno=None ------>sno=10383 ------>authors2=Liang YC ------>authors3=Chao JC ------>authors4=Tsai LH ------>authors5=Chang CC ------>authors6=Pan S ------>authors6_c= ------>authors=Chen SH ------>delete_flag=0 ------>SCI_JNo=None ------>authors2_c= ------>publish_area=0 ------>updateTitle=Protective effects of Ginkgo biloba extract on the ethanol-induced gastric ulcer in rats. ------>language=2 ------>check_flag=None ------>submit_date=None ------>country=None ------>no=24 ------>patent_SDate=None ------>update_bywho=None ------>publish_year=2005 ------>submit_flag=None ------>publish_month=6 |