Taipei Medical University

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Chen SH
------>authors3_c=
------>paper_class1=1
------>Impact_Factor=2.081
------>paper_class3=2
------>paper_class2=1
------>vol=11
------>confirm_bywho=hsuan
------>insert_bywho=lhtsai
------>Jurnal_Rank=58.2
------>authors4_c=
------>comm_author=
------>patent_EDate=None
------>authors5_c=
------>publish_day=28
------>paper_class2Letter=None
------>page2=3750
------>medlineContent=
------>unit=E0105
------>insert_date=20041124
------>iam=4
------>update_date=None
------>author=???
------>change_event=4
------>ISSN=1007-9327
------>authors_c=
------>score=500
------>journal_name=World Journal of Gastroenterology
------>paper_name=Protective effects of Ginkgo biloba extract on the ethanol-induced gastric ulcer in rats.
------>confirm_date=20091111
------>tch_id=059001
------>pmid=15968732
------>page1=3746
------>fullAbstract=AIM: To evaluate the preventive effect of Ginkgo biloba extract (GbE) on ethanol-induced gastric mucosal injuries in rats. METHODS: Female Wistar albino rats were used for the studies. We randomly divided the rats for each study into five subgroups: normal control, experimental control, and three experimental groups. The gastric ulcers were induced by instilling 1 mL 50% ethanol into the stomach. We gave GbE 8.75, 17.5, 26.25 mg/kg intravenously to the experimental groups respectively 30 min prior to the ulcerative challenge. We removed the stomachs 45 min later. The gastric ulcers, gastric mucus and the content of non-protein sulfhydryl groups (NP-SH), malondialdehyde (MDA), c-Jun kinase (JNK) activity in gastric mucosa were evaluated. The amount of gastric juice and its acidity were also measured. RESULTS: The findings of our study are as follows: (1) GbE pretreatment was found to provide a dose-dependent protection against the ethanol-induced gastric ulcers in rats; (2) the GbE pretreatment afforded a dose-dependent inhibition of ethanol-induced depletion of stomach wall mucus, NP-SH contents and increase in the lipid peroxidation (increase MDA) in gastric tissue; (3) gastric ulcer induced by ethanol produced an increase in JNK activity in gastric mucosa which also significantly inhibited by pretreatment with GbE; and (4) GbE alone had no inhibitory effect on gastric secretion in pylorus-ligated rats. CONCLUSION: The finding of this study showed that GbE significantly inhibited the ethanol-induced gastric lesions in rats. We suggest that the preventive effect of GbE may be mediated through: (1) inhibition of lipid peroxidation; (2) preservation of gastric mucus and NP-SH; and (3) blockade of cell apoptosis.
------>tmu_sno=None
------>sno=10383
------>authors2=Liang YC
------>authors3=Chao JC
------>authors4=Tsai LH
------>authors5=Chang CC
------>authors6=Pan S
------>authors6_c=
------>authors=Chen SH
------>delete_flag=0
------>SCI_JNo=None
------>authors2_c=
------>publish_area=0
------>updateTitle=Protective effects of Ginkgo biloba extract on the ethanol-induced gastric ulcer in rats.
------>language=2
------>check_flag=None
------>submit_date=None
------>country=None
------>no=24
------>patent_SDate=None
------>update_bywho=None
------>publish_year=2005
------>submit_flag=None
------>publish_month=6
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z