Taipei Medical University

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Kuo SH
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------>journal_name=J Clin Oncol
------>paper_name=Nuclear expression of BCL10 or nuclear factor kappa B predicts Helicobacter pylori-independent status of early-stage, high-grade mucosa-associated lymphoid tissue lymphomas
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------>fullAbstract=The genetic alterations underlying extranodal marginal zone B-cell lymphomas of mucosa-associated lymphoid tissue type are heterogeneous and show variation according to the tumor site. Here, we report a case of mucosa-associated lymphoid tissue lymphoma of the gallbladder with genetic characterization. This lymphoma, diagnosed in a 75-year-old woman who underwent cholecystectomy for suspected acute cholecystitis, presented as diffuse thickening of the gallbladder wall. The morphology was typical of mucosa-associated lymphoid tissue lymphoma, and by immunophenotype, the tumor cells were CD20+ CD5- CD10- CD23- CD43- BCL6- BCL2+ IgM+ IgD- lambda+, with moderate nuclear expression of BCL10. Interphase fluorescence in situ hybridization analysis on paraffin sections, using a fusion probe for API2/MALT1, demonstrated 2 fusion signals in most nuclei, bringing the first documentation of a t(11;18)(q21;q21) in this exceptional primary disease location.
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------>authors2=Chen LT
------>authors3=Yeh KH
------>authors4=Wu MS
------>authors5=Hsu HC
------>authors6=Chen CL
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------>authors=Kuo SH
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------>updateTitle=Primary mucosa-associated lymphoid tissue lymphoma of the gallbladder: report of a case harboring API2/MALT1 gene fusion.
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------>no=17
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------>publish_year=2004
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A B C D E F G H I J K L M N O P Q R S T U V W X Y Z