| Liou JP |
------>authors3_c= ------>paper_class1=1 ------>Impact_Factor=5.076 ------>paper_class3=2 ------>paper_class2=1 ------>vol=45 ------>confirm_bywho=None ------>insert_bywho=jpl ------>Jurnal_Rank=8.3 ------>authors4_c= ------>comm_author= ------>patent_EDate=None ------>authors5_c= ------>publish_day=1 ------>paper_class2Letter=None ------>page2=2562 ------>medlineContent= ------>unit=000 ------>insert_date=20050404 ------>iam=1 ------>update_date=None ------>author=??? ------>change_event=2 ------>ISSN= ------>authors_c= ------>score=500 ------>journal_name=J. Med. Chem. ------>paper_name=Synthesis and Structure-Activity Relationship of 2-Aminobenzophenone derivatives as antimitotic Agents. ------>confirm_date=None ------>tch_id=093131 ------>pmid=12036364 ------>page1=2556 ------>fullAbstract=A new type of inhibitor of tubulin polymerization was discovered on the basis of the combretastatin molecular skeleton. The lead compounds in this series, compounds 6 and 7, strongly inhibited tubulin polymerization in vitro and significantly arrested cells at the G(2)/M phase. Compounds 6 and 7 yielded 50- to 100-fold lower IC(50) values than did combretastatin A-4 against Colo 205, NUGC3, and HA22T human cancer cell lines as well as similar or greater growth inhibitory activities than did combretastain A-4 against DLD-1, HR, MCF-7, DU145, HONE-1, and MES-SA/DX5 human cancer cell lines. Structure-activity relationship information revealed that introduction of an amino group at the ortho position of the benzophenone ring plays an integral role for increased growth inhibition. ------>tmu_sno=None ------>sno=10643 ------>authors2=Chang CW ------>authors3=Song JS ------>authors4=Yeh CF ------>authors5=Hung HH ------>authors6=Liu SH, Hsieh HP ------>authors6_c= ------>authors=Liou JP ------>delete_flag=0 ------>SCI_JNo=None ------>authors2_c= ------>publish_area=0 ------>updateTitle=Synthesis and structure-activity relationship of 2-aminobenzophenone derivatives as antimitotic agents. ------>language=2 ------>check_flag=None ------>submit_date=None ------>country=None ------>no= ------>patent_SDate=None ------>update_bywho=None ------>publish_year=2002 ------>submit_flag=None ------>publish_month=1 |