Taipei Medical University

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Chen YC
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------>journal_name=J Cardiovasc Electrophysiol
------>paper_name=T-type Calcium Current in Electrical Activity of Cardiomyocytes Isolated from Rabbit Pulmonary Vein.
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------>pmid=15149427
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------>fullAbstract=INTRODUCTION: Pulmonary veins (PVs) are known to initiate paroxysmal atrial fibrillation. T-type calcium current (I(Ca-T)) has a role in normal and abnormal automaticity of cardiomyocytes. The aim of this study was to evaluate whether I(Ca-T) contributes to PV electrical activity. METHODS AND RESULTS: By whole-cell clamp techniques in rabbit myocytes, I(Ca-T) was identified in 12 (39%) of 31 PV cardiomyocytes with pacemaker activity, 2 (9%) of 23 PV cardiomyocytes without pacemaker activity, and 2 (15%) of 13 atrial myocytes (P < 0.05). Maximum I(Ca-L) and I(Ca-T) densities from PV cardiomyocytes with pacemaker activity were 6.87 +/- 2.17 pA/pF and 1.38 +/- 0.69 pA/pF, respectively. Nickel (40 microM) decreased the spontaneous activity in 5 (36%) of 14 PV cardiomyocytes (3.1 +/- 0.6 Hz vs 2.2 +/- 0.5 Hz, P < 0.05), reduced the amplitudes of delayed after depolarization from 13 +/- 1 mV to 7 +/- 1 mV (n = 4, P < 0.05) and inhibited transient inward currents from 1.2 +/- 0.2 pA/pF to 0.7 +/- 0.1 pA/pF (n = 11, P < 0.01). CONCLUSIONS: We conclude that I(Ca-T) contributes to PV pacemaker activity and triggered activity, which are of functional importance in PV arrhythmogenesis.
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------>authors2=Chen SA
------>authors3=Chen YJ
------>authors4=Tai CT
------>authors5=Chan P
------>authors6=Lin CI
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------>authors=Chen YC
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------>updateTitle=T-type calcium current in electrical activity of cardiomyocytes isolated from rabbit pulmonary vein.
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------>publish_year=2004
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A B C D E F G H I J K L M N O P Q R S T U V W X Y Z