Taipei Medical University

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Chang CC
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------>journal_name=World J Gastroenterol
------>paper_name=Anti-Helicobacter pylori therapy significantly reduces Helicobacter pylori -induced gastric mucosal damage in Mongolian gerbils
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------>fullAbstract=AIM: To investigate the effectiveness of 4 d~ anti-Helicobacter pylori therapy on the H pylori-infected Mongolian gerbils based on physiological and pathological changes. METHODS: We used 6-wk-old male gerbils orally inoculated with H pylori (ATCC43504, 2X10(8) CFU/mL). Seven weeks after H pylori inoculation, the animals of study group received 4 d~ anti-H pylori triple therapy (H pylori-eradicated group). Seven days later, all animals of the H pylori-eradicated and control groups (H pylori-infected and H pylori-uninfected groups) were sacrificed. We examined gastric mucosal lesions macroscopically, studied gastritis microscopically and determined the stomach weight ratio, myeloperoxidase (MPO) activity and prostaglandin (PG) E(2) level. RESULTS: The results showed that both macroscopic and histological gastric damages were significantly less in H pylori-eradicated group than H pylori-infected group. Stomach weight ratio, MPO activity and PGE(2) levels were significantly higher in H pylori-infected group than those in the other two groups. CONCLUSION: Four days~ anti-H pylori therapy was effective in the improvement of H pylori-induced gastric lesions in Mongolian gerbils.
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------>authors2=Chen SH
------>authors3=Lien GS
------>authors4=Lee YJ
------>authors5=Lou HY
------>authors6=Hsieh CR, Fan CL, Pan S
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------>authors=Chang CC
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------>updateTitle=Anti-Helicobacter pylori therapy significantly reduces Helicobacter pylori -induced gastric mucosal damage in Mongolian gerbils.
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------>publish_year=2005
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A B C D E F G H I J K L M N O P Q R S T U V W X Y Z