| You RI |
------>authors3_c= ------>paper_class1=1 ------>Impact_Factor=7.690 ------>paper_class3=2 ------>paper_class2=1 ------>vol=66 ------>confirm_bywho=shanghf ------>insert_bywho=mcchen ------>Jurnal_Rank=6.5 ------>authors4_c= ------>comm_author= ------>patent_EDate=None ------>authors5_c= ------>publish_day=15 ------>paper_class2Letter=None ------>page2=3061 ------>medlineContent= ------>unit=E0104 ------>insert_date=20050505 ------>iam=2 ------>update_date=None ------>author=??? ------>change_event=4 ------>ISSN= ------>authors_c= ------>score=458 ------>journal_name=Cancer Research ------>paper_name=Inhibition of Lymphotoxin-beta Receptor (LTbR)-mediated Cell Death by Survivin-deltaEx3 ------>confirm_date=20060425 ------>tch_id=092001 ------>pmid=16540654 ------>page1=3051 ------>fullAbstract=TNFSF14/LIGHT is a member of the tumor necrosis factor superfamily that binds to lymphotoxin-beta receptor (LTbetaR) to induce cell death via caspase-dependent and caspase-independent pathways. It has been shown that cellular inhibitor of apoptosis protein-1 inhibits cell death by binding to LTbetaR-TRAF2/TRAF3 complexes and caspases. In this study, we found that both Kaposi~s sarcoma-associated herpesvirus K7 (KSHV-K7), a viral inhibitor of apoptosis protein, and the structurally related protein survivin-DeltaEx3 could inhibit LTbetaR-mediated caspase-3 activation. However, only survivin-DeltaEx3 could protect cells from LTbetaR-mediated cell death. The differential protective effects of survivin-DeltaEx3 and KSHV-K7 can be attributed to the fact that survivin-DeltaEx3, but not KSHV-K7, is able to maintain mitochondrial membrane potential and inhibit second mitochondria-derived activator of caspase/DIABLO release. Moreover, survivin-DeltaEx3 is able to inhibit production of reactive oxygen species and can translocate from nucleus to cytosol to associate with apoptosis signal-regulating kinase 1 after activation of LTbetaR. Furthermore, survivin-DeltaEx3 protects LTbetaR-mediated cell death in caspase-3-deficient MCF-7 cells. Thus, survivin-DeltaEx3 is able to regulate both caspase-dependent and caspase-independent pathways, whereas inhibition of caspase-independent pathway is both sufficient and necessary for its protective effect on LTbetaR-mediated cell death. ------>tmu_sno=None ------>sno=11173 ------>authors2=Chen MC ------>authors3=Wang HW ------>authors4=Chou YC ------>authors5=Hsieh SL ------>authors6= ------>authors6_c= ------>authors=You RI ------>delete_flag=0 ------>SCI_JNo=None ------>authors2_c= ------>publish_area=0 ------>updateTitle=Inhibition of lymphotoxin-beta receptor-mediated cell death by survivin-DeltaEx3. ------>language=2 ------>check_flag=None ------>submit_date=None ------>country=None ------>no=6 ------>patent_SDate=None ------>update_bywho=None ------>publish_year=2006 ------>submit_flag=None ------>publish_month=3 |