| Wang CC |
------>authors3_c= ------>paper_class1=1 ------>Impact_Factor=1.143 ------>paper_class3=2 ------>paper_class2=1 ------>vol=17 ------>confirm_bywho=amel ------>insert_bywho=llyang ------>Jurnal_Rank=80.0 ------>authors4_c= ------>comm_author=1 ------>patent_EDate=None ------>authors5_c= ------>publish_day=1 ------>paper_class2Letter=None ------>page2=645 ------>medlineContent= ------>unit=G0100 ------>insert_date=20050510 ------>iam=4 ------>update_date=None ------>author=??? ------>change_event=4 ------>ISSN= ------>authors_c= ------>score=500 ------>journal_name=In Vivo. ------>paper_name=Effects of 6-Gingerol, an Antioxidant from Ginger, on Inducing Apoptosis in Human Leukemic HL-60 Cells ------>confirm_date=20081217 ------>tch_id=058001 ------>pmid=14758732 ------>page1=641 ------>fullAbstract=6-Gingerol, a naturally occurring plant phenol, is one of the major components of fresh ginger. In this paper, the antioxidative effects of 6-gingerol were detected by DPPH and DCFH assays and, as predicted, 6-gingerol as an antioxidant was shown to protect HL-60 cells from oxidative stress. Moreover, it induced cell death in promyelocytic leukemia HL-60 cells, caused DNA fragmentation and inhibited Bcl-2 expression in HL-60 cells. These results suggested that the inhibition of Bcl-2 expression in HL-60 cells might account for the mechanism of 6-gingerol-induced apoptosis. In the inhibitory assay, the cytotoxic effect of 6-gingerol could be prevented by catalase. We suggest that 6-gingerol induced cell death by mediating reactive oxygen species such as hydrogen peroxide and the superoxide anion. Therefore, the results showed that 6-gingerol induced apoptosis in HL-60 cells, not due to its antioxidative activity. ------>tmu_sno=None ------>sno=11272 ------>authors2=Chen LG ------>authors3=Lee LT ------>authors4=Yang LL ------>authors5= ------>authors6= ------>authors6_c= ------>authors=Wang CC ------>delete_flag=0 ------>SCI_JNo=None ------>authors2_c= ------>publish_area=0 ------>updateTitle=Effects of 6-gingerol, an antioxidant from ginger, on inducing apoptosis in human leukemic HL-60 cells. ------>language=2 ------>check_flag=None ------>submit_date=None ------>country=None ------>no=6 ------>patent_SDate=None ------>update_bywho=None ------>publish_year=2003 ------>submit_flag=None ------>publish_month=11 |