Taipei Medical University

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Chuang SS
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------>journal_name=Pathol Res Pract
------>paper_name=Primary bony peripheral T-cell lymphoma mimicking nasal type NK/T-cell lymphoma: a case report.
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------>fullAbstract=Primary bony lymphomas are rare, and nearly all are high-grade B-cell lymphomas. Natural killer (NK)/T-cell lymphomas are highly aggressive lymphomas of NK- or T-cell lineage with predominant extranodal presentation and are divided into nasal and nasal-type (extra-nasal). We report a primary bony peripheral T-cell lymphoma mimicking NK/T-cell lymphoma, nasal type. A 22-year-old Taiwanese male presented with a frontal skull bone mass noted for 3 weeks, and received craniectomy with tumor removal. His tumor showed extensive coagulative necrosis with angioinvasion by large lymphoma cells expressing CD2, CD8, CD16, CD43, CD45, CD45RO, CD56, T-cell intracellular antigen-1, and granzyme B, but not CD3, CD4, CD20, CD57, CD68, and betaF1. In situ hybridization for Epstein-Barr virus-encoded mRNA was negative. Polymerase chain reaction study of formalin-fixed tissue showed clonal rearrangement of the T-cell receptor-gamma chain gene. The diagnosis was peripheral T-cell lymphoma, unspecified subtype. The initial stage was I(EA). His lymphoma was refractory to chemotherapy, and bony metastases developed in the right iliac bone 2 months later. He died of disease after 6 months without autopsy. We emphasize the importance of detailed immunohistochemical and gene rearrangement studies for the classification of malignant lymphomas via a very rare primary bony lymphoma of peripheral T-cell subtype.
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------>authors2=Lin CN
------>authors3=Li CY
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------>authors=Chuang SS
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------>updateTitle=Primary bony peripheral T-cell lymphoma mimicking nasal type NK/T-cell lymphoma: a case report.
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------>publish_year=2002
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A B C D E F G H I J K L M N O P Q R S T U V W X Y Z