| Bai KJ |
------>authors3_c= ------>paper_class1=1 ------>Impact_Factor=8.689 ------>paper_class3=2 ------>paper_class2=1 ------>vol=172 ------>confirm_bywho=shiemin ------>insert_bywho=bkj ------>Jurnal_Rank=5.6 ------>authors4_c= ------>comm_author= ------>patent_EDate=None ------>authors5_c= ------>publish_day=1 ------>paper_class2Letter=None ------>page2=8 ------>medlineContent= ------>unit=E0109 ------>insert_date=20050715 ------>iam=1 ------>update_date=None ------>author=??? ------>change_event=4 ------>ISSN= ------>authors_c= ------>score=500 ------>journal_name=American Journal of Respiratory and Critical Care Medicine ------>paper_name=The Role of Hyaluronan Synthase 3 in Ventilator-induced Lung Injury ------>confirm_date=20061219 ------>tch_id=089122 ------>pmid=15790861 ------>page1=92 ------>fullAbstract=We recently found that low-molecular-weight hyaluronan was induced by cyclic stretch in lung fibroblasts and accumulated in lungs from animals with ventilator-induced lung injury. The low-molecular-weight hyaluronan produced by stretch increased interleukin-8 production in epithelial cells, and was accompanied by an upregulation of hyaluronan synthase-3 mRNA. We hypothesized that low-molecular-weight hyaluronan induced by high VT was dependent on hyaluronan synthase 3, and was associated with ventilator-induced lung injury. Effects of high VT ventilation in C57BL/6 wild-type and hyaluronan synthase-3 knockout mice were compared. Significantly increased neutrophil infiltration, macrophage inflammatory protein-2 production, and lung microvascular leak were found in wild-type animals ventilated with high VT. These reactions were significantly reduced in hyaluronan synthase-3 knockout mice, except the capillary leak. Wild-type mice ventilated with high VT were found to have increased low-molecular-weight hyaluronan in lung tissues and concomitant increased expression of hyaluronan synthase-3 mRNA, neither of which was found in hyaluronan synthase-3 knockout mice. We conclude that high VT induced low-molecular-weight hyaluronan production is dependent on de novo synthesis through hyaluronan synthase 3, and plays a role in the inflammatory response of ventilator-induced lung injury. ------>tmu_sno=None ------>sno=11555 ------>authors2=Spicer AP ------>authors3=Mascarenhas MM ------>authors4=Yu L ------>authors5=Ochoa CD ------>authors6=Garg HG, Quinn DA ------>authors6_c= ------>authors=Bai KJ ------>delete_flag=0 ------>SCI_JNo=None ------>authors2_c= ------>publish_area=0 ------>updateTitle=The role of hyaluronan synthase 3 in ventilator-induced lung injury. ------>language=2 ------>check_flag=None ------>submit_date=None ------>country=None ------>no=1 ------>patent_SDate=None ------>update_bywho=None ------>publish_year=2005 ------>submit_flag=None ------>publish_month=1 |