| Wang YF |
------>authors3_c=None ------>paper_class1=1 ------>Impact_Factor=None ------>paper_class3=1 ------>paper_class2=1 ------>vol=23 ------>confirm_bywho=tzengcr ------>insert_bywho=tzengcr ------>Jurnal_Rank=None ------>authors4_c=None ------>comm_author=1 ------>patent_EDate=None ------>authors5_c=None ------>publish_day=None ------>paper_class2Letter=None ------>page2=9 ------>medlineContent= ------>unit=E0111 ------>insert_date=20051212 ------>iam=3 ------>update_date=None ------>author=??? ------>change_event=4 ------>ISSN=None ------>authors_c=None ------>score=163 ------>journal_name=Bulletin of Taipei Medical College. ------>paper_name=Embryo toxic factors of peritoneal fluid from patients with endometriosis. ------>confirm_date=20051217 ------>tch_id=079009 ------>pmid=11167181 ------>page1=1 ------>fullAbstract=BACKGROUND: To determine whether there is a factor (or factors) in the peritoneal fluid of endometriosis patients that impairs embryo growth and embryo implantation. METHODS: Growth and development of two-cell mouse embryos which were cultured in media with peritoneal fluid from women with or without endometriosis and interleukin-1-beta (IL-1beta), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-alpha) levels in conditioned media were measured. RESULTS: The blastocyst rate in the non-endometriosis group was 46.4 +/- 31.1%, and that of the endometriosis group was 54.6 +/- 28.7%. Logistic regression analysis using the criteria of blastocyst development in 454 embryos, showed that the peritoneal fluid from endometriosis could promote (p=0.015) but IL-6 could arrest embryo growth to blastocyst (p=0.025). IL-1beta and TNF-alpha levels had no significant effect on blastocyst formation. CONCLUSION: Peritoneal fluid from women with endometriosis was not toxic to mouse embryo development. However, IL-6 in the peritoneal fluid deteriorated the growth and development of mouse embryos. ------>tmu_sno=None ------>sno=12176 ------>authors2=Lin NC ------>authors3=Tzeng CR ------>authors4=Chien LW ------>authors5=Chang SR ------>authors6=Chen AC,Wu CH,Cheng HW,ChenCY ------>authors6_c=None ------>authors=Wang YF ------>delete_flag=0 ------>SCI_JNo=None ------>authors2_c=None ------>publish_area=None ------>updateTitle=Mouse embryo toxicity of IL-6 in peritoneal fluids from women with or without endometriosis. ------>language=2 ------>check_flag=None ------>submit_date=None ------>country=None ------>no= ------>patent_SDate=None ------>update_bywho=None ------>publish_year=1994 ------>submit_flag=None ------>publish_month=None |