| Rauhala P |
------>authors3_c=None ------>paper_class1=1 ------>Impact_Factor=2.618 ------>paper_class3=2 ------>paper_class2=1 ------>vol=207 ------>confirm_bywho=kyhsu ------>insert_bywho=chiueh ------>Jurnal_Rank=17.3 ------>authors4_c=None ------>comm_author=1 ------>patent_EDate=None ------>authors5_c=None ------>publish_day=None ------>paper_class2Letter=None ------>page2=95 ------>medlineContent= ------>unit=G0100 ------>insert_date=20051219 ------>iam=7 ------>update_date=None ------>author=??? ------>change_event=6 ------>ISSN=None ------>authors_c=None ------>score=500 ------>journal_name=Toxicol Appl Pharmacol. ------>paper_name=Neuroprotective properties of nitric oxide and S-nitrosoglutathione. ------>confirm_date=20051220 ------>tch_id=092016 ------>pmid=15987648 ------>page1=91 ------>fullAbstract=Oxidative stress and apoptosis may play an important role in the neurodegeneration. The present paper outlines antioxidative and antiapototic mechanisms of nitric oxide and S-nitrosothiols, which could mediate neuroprotection. Nitric oxide generated by nitric oxide synthase or released from an endogenous S-nitrosothiol, S-nitrosoglutathione may up-regulate antioxidative thioredoxin system and antiapototic Bcl-2 protein through a cGMP-dependent mechanism. Moreover, nitric oxide radicals have been shown to have direct antioxidant effect through their reaction with free radicals and iron-oxygen complexes. In addition to serving as a stabilizer and carrier of nitric oxide, S-nitrosoglutathione may have protective effect through transnitrosylation reactions. Based on these new findings, a hypothesis arises that the homeostasis of nitric oxide, S-nitrosothiols, glutathione, and thioredoxin systems is important for protection against oxidative stress, apoptosis, and related neurodegenerative disorders. ------>tmu_sno=None ------>sno=12344 ------>authors2=Andoh T ------>authors3=Chiueh CC ------>authors4= ------>authors5= ------>authors6= ------>authors6_c=None ------>authors=Rauhala P ------>delete_flag=0 ------>SCI_JNo=None ------>authors2_c=None ------>publish_area=None ------>updateTitle=Neuroprotective properties of nitric oxide and S-nitrosoglutathione. ------>language=2 ------>check_flag=None ------>submit_date=None ------>country=None ------>no= ------>patent_SDate=None ------>update_bywho=None ------>publish_year=2005 ------>submit_flag=None ------>publish_month=None |