| Yeh SD |
------>authors3_c=None ------>paper_class1=2 ------>Impact_Factor=None ------>paper_class3=0 ------>paper_class2=0 ------>vol=Mach ------>confirm_bywho=lm ------>insert_bywho=yehsd ------>Jurnal_Rank=None ------>authors4_c=None ------>comm_author=1 ------>patent_EDate=None ------>authors5_c=None ------>publish_day=1 ------>paper_class2Letter=None ------>page2=40 ------>medlineContent= ------>unit=E0117 ------>insert_date=20051221 ------>iam=1 ------>update_date=None ------>author=??? ------>change_event=4 ------>ISSN= ------>authors_c=None ------>score=468 ------>journal_name=Program of 2005 Annual meeting and 23rd general scientific meeting of the Taiwanese Association of Andrology ------>paper_name=Infertility with Defective Spermatogenesis and Hypotestosteronemia in Male Mice Lacking the Androgen in Sertoli Cells ------>confirm_date=20060426 ------>tch_id=091054 ------>pmid=15107499 ------>page1=40 ------>fullAbstract=Androgens and the androgen receptor (AR) play important roles in male fertility, although the detailed mechanisms, particularly how androgen/AR influences spermatogenesis in particular cell types, remain unclear. Using a Cre-Lox conditional knockout strategy, we generated a tissue-specific knockout mouse with the AR gene deleted only in Sertoli cells (S-AR(-/y)). Phenotype analyses show the S-AR(-/y) mice were indistinguishable from WT AR mice (B6 AR(+/y)) with the exception of testes, which were significantly atrophied. S-AR(-/y) mice were infertile, with spermatogenic arrest predominately at the diplotene premeiotic stage and almost no sperm detected in the epididymides. S-AR(-/y) mice also have lower serum testosterone concentrations and higher serum leuteinizing hormone concentrations than B6 AR(+/y) mice. Further mechanistic studies demonstrated that S-AR(-/y) mice have defects in the expression of anti-Mullerian hormone, androgen-binding protein, cyclin A1, and sperm-1, which play important roles in the control of spermatogenesis and/or steroidogenesis. Together, our Sertoli cell-specific AR knockout mice provide in vivo evidence of the need for functional AR in Sertoli cells to maintain normal spermatogenesis and testosterone production, and ensure normal male fertility. ------>tmu_sno=None ------>sno=12380 ------>authors2=Chen YT ------>authors3=Yeh SY ------>authors4=Chiang HS ------>authors5=Chang CS ------>authors6= ------>authors6_c=None ------>authors=Yeh SD ------>delete_flag=0 ------>SCI_JNo=None ------>authors2_c=None ------>publish_area=1 ------>updateTitle=Infertility with defective spermatogenesis and hypotestosteronemia in male mice lacking the androgen receptor in Sertoli cells. ------>language=1 ------>check_flag=None ------>submit_date=None ------>country=None ------>no= ------>patent_SDate=None ------>update_bywho=None ------>publish_year=2005 ------>submit_flag=None ------>publish_month=1 |