| Shyu KG |
------>authors3_c=None ------>paper_class1=1 ------>Impact_Factor=2.351 ------>paper_class3=2 ------>paper_class2=1 ------>vol=28 ------>confirm_bywho=None ------>insert_bywho=shyukg ------>Jurnal_Rank=47.5 ------>authors4_c=None ------>comm_author= ------>patent_EDate=None ------>authors5_c=None ------>publish_day=None ------>paper_class2Letter=None ------>page2=1972 ------>medlineContent= ------>unit=000 ------>insert_date=20060116 ------>iam=1 ------>update_date=None ------>author=??? ------>change_event=1 ------>ISSN=None ------>authors_c=None ------>score=500 ------>journal_name=Neuroreport ------>paper_name=PP2 inhibits glutamate release from nerve endings by affecting vesicle mobilization ------>confirm_date=None ------>tch_id=092067 ------>pmid=16272889 ------>page1=1969 ------>fullAbstract=Src kinase is widely expressed in the brain and its inhibition with PP2 has previously been shown to depress depolarization-evoked glutamate release from rat cerebrocortical synaptosomes by reducing voltage-dependent Ca2+ entry. In this study, we further showed that the inhibitory effect of PP2 on 4-aminopyridine-evoked glutamate release results from a reduction of vesicular exocytosis and not from an inhibition of non-vesicular release. In addition, PP2 significantly inhibited ionomycin-induced or hypertonic sucrose-induced glutamate release. Also, disruption of cytoskeleton organization with cytochalasin D occluded the inhibitory action of PP2 on 4-aminopyridine and ionomycin-evoked glutamate release. These results suggest that PP2-mediated inhibition of glutamate release involves the modulation of some exocytotic steps, possibly through a regulation of actin cytoskeleton dynamics. ------>tmu_sno=None ------>sno=12424 ------>authors2=Jow GM ------>authors3=Lee YJ ------>authors4=Wang SJ ------>authors5= ------>authors6= ------>authors6_c=None ------>authors=Shyu KG ------>delete_flag=0 ------>SCI_JNo=None ------>authors2_c=None ------>publish_area=None ------>updateTitle=PP2 inhibits glutamate release from nerve endings by affecting vesicle mobilization. ------>language=2 ------>check_flag=None ------>submit_date=None ------>country=None ------>no= ------>patent_SDate=None ------>update_bywho=None ------>publish_year=2006 ------>submit_flag=None ------>publish_month=None |