| Sheng KH |
------>authors3_c=None ------>paper_class1=1 ------>Impact_Factor=5.483 ------>paper_class3=2 ------>paper_class2=1 ------>vol=6 ------>confirm_bywho=jschu ------>insert_bywho=sschuang ------>Jurnal_Rank=9.8 ------>authors4_c=None ------>comm_author= ------>patent_EDate=None ------>authors5_c=None ------>publish_day=None ------>paper_class2Letter=None ------>page2=1065 ------>medlineContent= ------>unit=E0102 ------>insert_date=20060204 ------>iam=3 ------>update_date=None ------>author=??? ------>change_event=4 ------>ISSN=None ------>authors_c=None ------>score=500 ------>journal_name=Protemics ------>paper_name=Search for the tumor-related proteins of transition cell carcinoma in Taiwan by proteomic analysis. ------>confirm_date=20060206 ------>tch_id=094004 ------>pmid=16400682 ------>page1=1058 ------>fullAbstract=To better understand the carcinogenesis of bladder cancer in Taiwan, we utilized the proteomic approach to search for potential biomarkers of transitional cell carcinoma (TCC). Analysis by 2-DE and MS/MS indicated that seven proteins are down-regulated and three proteins up-regulated in grade III samples as compared with those of grade II. Of these deregulated proteins, fatty acid binding proteins, annexin V, heat-shock protein 27, and lactate dehydrogenase have been shown to be associated with bladder cancer. Our studies also found altered expression of a group of proteins that have not been documented previously in bladder cancer, including annexin I, 15-hydroxyprostaglandin dehydrogenase, galectin-1, lysophospholipase and mitochondrial short-chain enoyl-coenzyme A hydratase 1 precursor. These results illustrate a pattern of differential protein expression between low- and high-grade tumors and it may be utilized as the molecular fingerprinting of a subset of bladder cancers. In addition, the present study provides a valuable resource in the study of pathological mechanisms in cancers of urothelial origin. The immunohistochemical staining of grade II and III TCC samples with antiserum to annexin I protein was utilized to confirm that the annexin I protein is up-regulated in grade III TCC. ------>tmu_sno=None ------>sno=12524 ------>authors2=Yao YC ------>authors3=Chuang SS ------>authors4=Wu H ------>authors5=Wu TF ------>authors6= ------>authors6_c=None ------>authors=Sheng KH ------>delete_flag=0 ------>SCI_JNo=None ------>authors2_c=None ------>publish_area=0 ------>updateTitle=Search for the tumor-related proteins of transition cell carcinoma in Taiwan by proteomic analysis. ------>language=2 ------>check_flag=None ------>submit_date=None ------>country=None ------>no= ------>patent_SDate=None ------>update_bywho=None ------>publish_year=2006 ------>submit_flag=None ------>publish_month=None |