Taipei Medical University

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Liu HC
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------>journal_name=Dement Geriatr Cogn Disord.
------>paper_name=38. Proteomic Identification of Lower Apolipoprotein A-I in Alzheimer's Disease.
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------>fullAbstract=Many researches have been trying to find the potential biomarkers for Alzheimer~s disease (AD). We hereby used the proteomics method to search for protein expression differences in the serum between AD patients and controls. We enrolled 59 AD patients and 74 age- and sex-matched controls in this study. Ten AD patients and 10 controls were selected for proteomic analysis. Apolipoprotein A-I (ApoA-I) was found to have a lower expression in the AD group by a proteomics two-dimensional gel electrophoresis study. We further measured the serum ApoA-I level which was significantly lower in the AD patients (112.29 +/- 21.33 mg/dl) in comparison to the controls (144.53 +/- 19.91 mg/dl; p < 0.0002). Lower serum ApoA-I levels might be a potential biomarker for AD.
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------>authors2=Hu CJ
------>authors3=Chang JG
------>authors4=Sung SM
------>authors5=Lee LS
------>authors6=Yuan RY, Leu SJ.
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------>authors=Liu HC
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------>updateTitle=Proteomic identification of lower apolipoprotein A-I in Alzheimer~s disease.
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------>publish_year=2006
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A B C D E F G H I J K L M N O P Q R S T U V W X Y Z