| Yen JH |
------>authors3_c=None ------>paper_class1=1 ------>Impact_Factor=2.136 ------>paper_class3=2 ------>paper_class2=1 ------>vol=102 ------>confirm_bywho=ryyuan ------>insert_bywho=chaurjongh ------>Jurnal_Rank=49.5 ------>authors4_c=None ------>comm_author= ------>patent_EDate=None ------>authors5_c=None ------>publish_day=1 ------>paper_class2Letter=None ------>page2=97 ------>medlineContent= ------>unit=E0123 ------>insert_date=20060208 ------>iam=7 ------>update_date=None ------>author=??? ------>change_event=4 ------>ISSN= ------>authors_c=None ------>score=458 ------>journal_name=Immunol Lett. ------>paper_name=37. Natural resistance-associated macrophage protein 1 gene polymorphisms in rheumatoid arthritis. ------>confirm_date=20060208 ------>tch_id=093052 ------>pmid=16125248 ------>page1=91 ------>fullAbstract=OBJECTIVES: To investigate the association of natural resistance-associated macrophage protein 1 gene (NRAMP1) polymorphisms with rheumatoid arthritis (RA) in Taiwan. METHODS: NRAMP1 polymorphisms were determined from 113 RA patients and 74 healthy controls using the polymerase chain reaction/restriction fragment length polymorphism method. RESULTS: The genotype frequencies of NRAMP1 823 C/C, 1703G/G (543D/D), and 1729+55 del 4 TGTG+/+ (244/244) were significantly higher in patients with RA than in controls. Similar findings were also evident in allele frequencies and allele carriage frequencies of 823C, 1703G (543D), and 1729+55 del 4 TGTG+ (244). The associations of these polymorphisms with RA were independent of HLA-DR4. Linkage disequilibria could be found between 823C and 1703G, and between 1703G and 1729+55 del 4 TGTG+. The estimated haplotype frequency of NRAMP1 823C/1703G/1729+55 del 4 TGTG+ was significantly increased in RA patients compared with controls. We also found that patients with 823 C/C had a significantly lower prevalence of rheumatoid nodule than those without 823 C/C. CONCLUSION: NRAMP1 823C, 1703G (543D), and 1729+55 del 4 TGTG+ (244) are precipitating factors for the development of RA in Taiwan. The estimated NRAMP1 823C/1703G/1729+del 4 TGTG+ haplotype is associated with susceptibility to RA. NRAMP1 823 C/C prevents the development of rheumatoid nodule in RA patients. ------>tmu_sno=None ------>sno=12653 ------>authors2=Lin CH ------>authors3=Tsai WC ------>authors4=Ou TT ------>authors5=Wu CC ------>authors6=Hu CJ, Liu HW ------>authors6_c=None ------>authors=Yen JH ------>delete_flag=0 ------>SCI_JNo=None ------>authors2_c=None ------>publish_area=0 ------>updateTitle=Natural resistance-associated macrophage protein 1 gene polymorphisms in rheumatoid arthritis. ------>language=2 ------>check_flag=None ------>submit_date=None ------>country=None ------>no= ------>patent_SDate=None ------>update_bywho=None ------>publish_year=2006 ------>submit_flag=None ------>publish_month=1 |