Taipei Medical University

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Yang V WC
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------>insert_date=20060221
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------>journal_name=presented at Taiwanese Society for Reproductive Medicine (TSRM) 2003 Annual Meeting, Taipei, Taiwan
------>paper_name=Identification of Serum Markers for Endometriosis
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------>fullAbstract=BACKGROUND: Endometriosis is a common gynecological disease. This study aimed to screen proteins that were expressed differently in patients with endometriosis versus normal controls using proteomic techniques, surface-enhanced laser desorption/ionization time-of-flight mass spectrometry (SELDI-TOF-MS). METHODS: Protein chip SELDI-TOF-MS combines the advantages of microarray and mass spectrometry, and can screen latent markers in sera of patients with endometriosis. Serum samples from patients and normal volunteers were analyzed by SELDI-TOF-MS. RESULTS: After comparing the serum protein spectra of 36 patients with 24 normal controls, 24 differently expressed potential biomarkers (P < 0.01) were identified. Using Biomarker Pattern software, we established a tree model of the 60 serum protein spectra. When using the three biomarkers to classify the samples, the sensitivity for diagnosing endometriosis was 91.7%, specificity was 95.8%, and coincidence rate was 93.3%. Then we used serum samples from 12 patients and 8 normal controls to validate the tree model and report the sensitivity for diagnosing endometriosis was 91.7%, specificity was 75%, and coincidence rate was 85%. CONCLUSIONS: SELDI-TOF-MS may be a useful tool in high-risk population screening for endometriosis. The identification and application of the biomarkers need to further study.
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------>authors2=HuangYJ
------>authors3=Wang A. HJ
------>authors4=Tzeng CR
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------>authors=Yang V WC
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------>updateTitle=Effect of surface-enhanced laser desorption/ionization time-of-flight mass spectrometry on identifing biomarkers of endometriosis.
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------>publish_year=2003
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------>publish_month=12
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z