Chen CM |
------>authors3_c= ------>paper_class1=1 ------>Impact_Factor=1.974 ------>paper_class3=2 ------>paper_class2=1 ------>vol=16 ------>confirm_bywho=shiemin ------>insert_bywho=hsun ------>Jurnal_Rank=43.9 ------>authors4_c=??? ------>comm_author= ------>patent_EDate=None ------>authors5_c= ------>publish_day=1 ------>paper_class2Letter=None ------>page2=220 ------>medlineContent= ------>unit=E0113 ------>insert_date=20060307 ------>iam=4 ------>update_date=None ------>author=??? ------>change_event=4 ------>ISSN= ------>authors_c=??? ------>score=475 ------>journal_name=Pul Pharmacol Ther ------>paper_name=Methylprednisolone effects on oxygenation and histology in a rat model of acute lung injuyr. ------>confirm_date=20060503 ------>tch_id=067009 ------>pmid=12850124 ------>page1=215 ------>fullAbstract=We examined the effects of methylprednisolone on gas exchange, pressure-volume curve, lavage fluid inflammatory cell counts, protein content, surfactant pool size, and lung histology in a rat model of paraquat-induced lung injury. Twenty-three adult male Sprague-Dawley rats received intraperitoneal paraquat injection (35 mg/kg) and were randomly divided into three groups: (1). control group received no further treatment; (2). 1-dose methylprednisolone group received a concomitant intraperitoneal methylprednisolone injection (30 mg/kg); (3). 3-dose methylprednisolone group received a concomitant and daily intraperitoneal methylprednisolone injection (30 mg/kg) for three doses. Three days after paraquat injection, the rat was ventilated for 90 min, a static pressure-volume curve and bronchoalveolar lavage was performed, and postmortem histology was examined. Surfactant pool size of the 3-dose methylprednisolone group was significantly increased when compared with the control and 1-dose methylprednisolone groups. Methylprednisolone treatment increased oxygenation and the value was statistically significant for 3-dose methylprednisolone group at 90 min of ventilation. Inflammatory cell counts in bronchoalveolar lavage fluid and lung injury score were decreased as the methylprednisolone dose increased. We conclude that high-dose methylprednisolone treatment increased surfactant pool size and improved lung histology of paraquat-injured lungs but this augmentation could not significantly improve oxygenation throughout the ventilation period. ------>tmu_sno=None ------>sno=13112 ------>authors2=Wang LF ------>authors3=Su B ------>authors4=Hsu HH ------>authors5= ------>authors6= ------>authors6_c= ------>authors=Chen CM ------>delete_flag=0 ------>SCI_JNo=None ------>authors2_c= ------>publish_area=0 ------>updateTitle=Methylprednisolone effects on oxygenation and histology in a rat model of acute lung injury. ------>language=2 ------>check_flag=None ------>submit_date=None ------>country=None ------>no= ------>patent_SDate=None ------>update_bywho=None ------>publish_year=2003 ------>submit_flag=None ------>publish_month=1 |