| Lin CM |
------>authors3_c=??? ------>paper_class1=1 ------>Impact_Factor=2.018 ------>paper_class3=2 ------>paper_class2=1 ------>vol=14 ------>confirm_bywho=cmshih ------>insert_bywho=cmlin ------>Jurnal_Rank=33.3 ------>authors4_c=??? ------>comm_author= ------>patent_EDate=None ------>authors5_c=??? ------>publish_day=1 ------>paper_class2Letter=None ------>page2=4409 ------>medlineContent= ------>unit=E0103 ------>insert_date=20060429 ------>iam=1 ------>update_date=None ------>author=??? ------>change_event=4 ------>ISSN= ------>authors_c=??? ------>score=500 ------>journal_name=Bioorg Med Chem ------>paper_name=6-Acyl-4-aryl/alkyl-5,7-dihydroxycoumarins as anti-inflammatory agents. ------>confirm_date=20060815 ------>tch_id=081006 ------>pmid=16540334 ------>page1=4402 ------>fullAbstract=A series of coumarin derivatives were synthesized in two steps from phloroglucinol. The anti-inflammatory activities of these derivatives were evaluated by means of inhibiting NO production in LPS-induced RAW 264.7 cells. Derivatives 3, 8, 10, 11, and 13 exhibited low micromolar levels of anti-inflammatory activities, and these derivatives also protected DNA against hydroxyl radical attack. Coumarin derivative 8 was the most potent derivative among those tested herein against NO production in LPS-induced RAW 264.7 cells with an IC(50) value of 7.6 microM, and it effectively reduced the hydroxyl radical production by 50% at 100 microM in the electron spin resonance study. ------>tmu_sno=None ------>sno=13474 ------>authors2=Huang ST ------>authors3=Lee FW ------>authors4=Kuo HS ------>authors5=Lin MH ------>authors6= ------>authors6_c= ------>authors=Lin CM ------>delete_flag=0 ------>SCI_JNo=None ------>authors2_c=??? ------>publish_area=0 ------>updateTitle=6-Acyl-4-aryl/alkyl-5,7-dihydroxycoumarins as anti-inflammatory agents. ------>language=2 ------>check_flag=None ------>submit_date=None ------>country=None ------>no=13 ------>patent_SDate=None ------>update_bywho=None ------>publish_year=2006 ------>submit_flag=None ------>publish_month=7 |