| Lian,iyo-zy |
------>authors3_c=??? ------>paper_class1=2 ------>Impact_Factor=None ------>paper_class3=0 ------>paper_class2=0 ------>vol=p ------>confirm_bywho=tlc ------>insert_bywho=lcpan ------>Jurnal_Rank=None ------>authors4_c=?? ------>comm_author= ------>patent_EDate=None ------>authors5_c= ------>publish_day=1 ------>paper_class2Letter=None ------>page2= ------>medlineContent= ------>unit=D0700 ------>insert_date=20060502 ------>iam=2 ------>update_date=None ------>author=??? ------>change_event=6 ------>ISSN= ------>authors_c=??? ------>score=66 ------>journal_name=2005 ???????????? ------>paper_name=??????-??????MG-63????????? ------>confirm_date=20070427 ------>tch_id=087005 ------>pmid=19846944 ------>page1=48 ------>fullAbstract=BACKGROUND: Osteoprotegerin (OPG) expression participates in the pathophysiology of osteoblastic metastasis in prostate cancer. MATERIALS AND METHODS: We investigated whether the expression of OPG of PC-3 prostate cancer cells grown in 3-D collagen gels is stimulated by co-culture with MG-63 osteoblast-like cells. The expression of Runx2 (Cbfa1) and OPG were assessed by reverse transcription-polymerase chain reaction and Western blot analysis. RESULTS: OPG and Runx2 were expressed in both PC-3 and MG-63 cells. OPG expression was remarkably enhanced in PC-3 cells grown in co-culture with MG-63 cells in a time-dependent manner. Runx2 expression of PC-3 cells was not altered by their co-culture with MG-63 cells. OPG expression of PC-3 cells was altered neither by insulin-like growth factor I (IGF-1), transforming growth factor beta1 (TGFbeta1), interleukin 6 (IL-6) nor by dexamethasone and zoledronic acid exogenously added to PC-3 cells. CONCLUSION: The enhancement of the OPG expression in PC-3 cells by MG-63 cells is not mediated by IGF-1, IL-6 and TGFbeta1. ------>tmu_sno=None ------>sno=13591 ------>authors2=Pan,Li-Chern ------>authors3=Fong,Ker-Lin ------>authors4=Pei,Shin ------>authors5= ------>authors6= ------>authors6_c= ------>authors=Lian,iyo-zy ------>delete_flag=0 ------>SCI_JNo=None ------>authors2_c=??? ------>publish_area=1 ------>updateTitle=MG-63 osteoblast-like cells enhance the osteoprotegerin expression of PC-3 prostate cancer cells. ------>language=1 ------>check_flag=None ------>submit_date=None ------>country=None ------>no=076 ------>patent_SDate=None ------>update_bywho=None ------>publish_year=2006 ------>submit_flag=None ------>publish_month=1 |