| Lai, Wen-Fu |
------>authors3_c=??? ------>paper_class1=6 ------>Impact_Factor=None ------>paper_class3=0 ------>paper_class2=0 ------>vol= ------>confirm_bywho=tlc ------>insert_bywho=lcpan ------>Jurnal_Rank=None ------>authors4_c=??? ------>comm_author= ------>patent_EDate=None ------>authors5_c=??? ------>publish_day=22 ------>paper_class2Letter=None ------>page2= ------>medlineContent= ------>unit=D0700 ------>insert_date=20060503 ------>iam=2 ------>update_date=None ------>author=??? ------>change_event=4 ------>ISSN= ------>authors_c=??? ------>score=3 ------>journal_name=US/European patent ------>paper_name=Bone Implant ------>confirm_date=20070430 ------>tch_id=087005 ------>pmid=19916684 ------>page1= ------>fullAbstract=BACKGROUND AND PURPOSE: Factors that lead to periprosthetic bone loss following total hip arthroplasty (THA) may not only depend on biomechanical implant-related factors, but also on various patient-related factors. We investigated the association between early changes in periprosthetic bone mineral density (BMD) and patient-related factors. PATIENTS AND METHODS: 39 female patients underwent cementless THA (ABG II) with ceramic-ceramic bearing surfaces. Periprosthetic BMD in the proximal femur was determined with DXA after surgery and at 3, 6, 12, and 24 months. 27 patient-related factors were analyzed for their value in prediction of periprosthetic bone loss. RESULTS: Total periprosthetic BMD was temporarily reduced by 3.7% at 3 months (p < 0.001), by 3.8% at 6 months (p < 0.01), and by 2.6% at 12 months (p < 0.01), but recovered thereafter up to 24 months. Preoperative systemic osteopenia and osteoporosis, but not the local BMD of the operated hip, was predictive of bone loss in Gruen zone 7 (p = 0.04), which was the only region with a statistically significant decrease in BMD (23%, p < 0.001) at 24 months. Preoperative serum markers of bone turnover predicted the early temporary changes of periprosthetic BMD. The other patient-related factors failed to show any association with the periprosthetic BMD changes. INTERPRETATION: Female patients with low systemic BMD show greater bone loss in Gruen zone 7 after cementless THA than patients with normal BMD. Systemic DXA screening for osteoporosis in postmenopausal patients before THA could be used to identify patients in need of prophylactic anti-resorptive therapy. ------>tmu_sno=None ------>sno=13626 ------>authors2=Pan, Li-Chern ------>authors3=Lim, Pau-Yee ------>authors4=Oung, Jun-Chou ------>authors5=Chen,Chun-Wei ------>authors6= ------>authors6_c= ------>authors=Lai, Wen-Fu ------>delete_flag=0 ------>SCI_JNo=None ------>authors2_c=??? ------>publish_area=0 ------>updateTitle=Female patients with low systemic BMD are prone to bone loss in Gruen zone 7 after cementless total hip arthroplasty. ------>language=1 ------>check_flag=None ------>submit_date=None ------>country=None ------>no= ------>patent_SDate=None ------>update_bywho=None ------>publish_year=2005 ------>submit_flag=None ------>publish_month=2 |