| Kuo YC |
------>authors3_c= ------>paper_class1=1 ------>Impact_Factor=1.639 ------>paper_class3=2 ------>paper_class2=1 ------>vol=71 ------>confirm_bywho=hsu0320 ------>insert_bywho=hsu0320 ------>Jurnal_Rank=26.8 ------>authors4_c= ------>comm_author= ------>patent_EDate=None ------>authors5_c= ------>publish_day=1 ------>paper_class2Letter=None ------>page2=415 ------>medlineContent= ------>unit=G0200 ------>insert_date=20060508 ------>iam=7 ------>update_date=None ------>author=??? ------>change_event=4 ------>ISSN= ------>authors_c= ------>score=496 ------>journal_name=Planta Medica ------>paper_name=Inhibitory effects of acylated kaempferol glycosides from the leaves of Ciinnamomum kotoense on the proliferation of human peripheral blood mononuclear cells ------>confirm_date=20060508 ------>tch_id=074001 ------>pmid=15931577 ------>page1=412 ------>fullAbstract=A new chemical entity, namely kaempferol 3- O-alpha-L-[2-(Z)-p-coumaroyl-4-(E)-p-coumaroyl]rhamnopyranoside (1), and the known kaempferol 3-O-alpha-L-[2,4-di-(E)-p-coumaroyl]rhamnopyranoside (2) have been isolated from the methanolic extract of leaves of Cinnamomum kotoense. Structural elucidation of compounds 1 and 2 were achieved on the basis of spectroscopic analysis. The effects of compounds 1 and 2 on phytohemagglutinin (PHA) stimulated cell proliferation were studied towards human peripheral blood mononuclear cells (PBMC). The results indicated that compounds 1 and 2 suppressed PBMC proliferation induced by PHA with an IC50 value of 5.0 +/- 1.3 and 6.0 +/- 1.5 microM, respectively. Interleukin-2 production in activated PBMC inhibited by compounds 1 and 2 were in a concentration-dependent manner. Therefore, we suggested that compounds 1 and 2 in C. kotoense were likely the growth modulators for PBMC. ------>tmu_sno=None ------>sno=13859 ------>authors2=Lu CK ------>authors3=Huang LW ------>authors4=Kuo YH ------>authors5=Chang C ------>authors6=Hsu FL, Lee TH ------>authors6_c= ------>authors=Kuo YC ------>delete_flag=0 ------>SCI_JNo=None ------>authors2_c= ------>publish_area=0 ------>updateTitle=Inhibitory effects of acylated kaempferol glycosides from the leaves of Cinnamomum kotoense on the proliferation of human peripheral blood mononuclear cells. ------>language=2 ------>check_flag=None ------>submit_date=None ------>country=None ------>no= ------>patent_SDate=None ------>update_bywho=None ------>publish_year=2005 ------>submit_flag=None ------>publish_month=1 |