Taipei Medical University

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Chen CJ
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------>journal_name=Combinatorial Chemistry & High Throughput Screening
------>paper_name=A Screening Platform for Compounds with Potential Immuno-Regulatory Activities Using Human Cord Blood Mononuclear Cells.
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------>fullAbstract=A systematic and combinatorial approach was adopted using human umbilical cord blood mononuclear cells (hUCB-MNCs) to screen for potential immuno-regulatory compounds. The hUCB-MNCs contain several types of immunogenic cells, which are a suitable material to mimic the in vivo immuno-response after drug treatment. hUCB-MNCs were treated with various natural products such as quercetin, astaxanthin, caffeic acid, bilobalide, eugenol, rutin and gamma-dodecalactone (gamma-DDL). Phenotypic expression analysis revealed that the subpopulation of CD3(+) T cells, CD56(+) NK cells and CD1a(+) dendritic cells apparently increased after being treated with gamma-DDL for 6 days. The expression of CD56 reached a maximum at 72 h with a dose-dependent relationship. The NK cells activation marker (CD69) also elevated following gamma-DDL treatment. These results demonstrated that the gamma-DDL has immuno-regulatory effects to enhance cord blood NK cells population and bioactivities. Such a high-throughput methodology using hUCB-MNCs may be an effective platform for systematically screening potential immuno-regulatory compounds.
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------>authors2=Tsai CC
------>authors3=Hsieh JF
------>authors4=Chien CM
------>authors5=Wu TH
------>authors6=Chen ST
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------>authors=Chen CJ
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------>updateTitle=A screening platform for compounds with potential immuno-regulatory activities using human cord blood mononuclear cells.
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------>no=10
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------>publish_year=2006
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A B C D E F G H I J K L M N O P Q R S T U V W X Y Z