| How-Ran Guo |
------>authors3_c= ------>paper_class1=1 ------>Impact_Factor=1.312 ------>paper_class3=2 ------>paper_class2=1 ------>vol=82 ------>confirm_bywho=leehorng ------>insert_bywho=hoyuansn ------>Jurnal_Rank=9.4 ------>authors4_c= ------>comm_author= ------>patent_EDate=None ------>authors5_c= ------>publish_day=1 ------>paper_class2Letter=None ------>page2=109 ------>medlineContent= ------>unit=E0310 ------>insert_date=20061106 ------>iam=4 ------>update_date=None ------>author=??? ------>change_event=4 ------>ISSN= ------>authors_c= ------>score=500 ------>journal_name=International Journal of Radiation Biology ------>paper_name=Staurosporine modulates radiosensitivity and radiation-induced apoptosis in U937 cells ------>confirm_date=20071206 ------>tch_id=084007 ------>pmid=16546908 ------>page1=97 ------>fullAbstract=PURPOSE: The present study aims at investigating the involvement of several genes in the cell cycle distribution and apoptosis in U937 cells, a cell line lacking functional p53 protein, after combined treatment with staurosporine and irradiation. MATERIALS AND METHODS: Using a DNA fragmentation assay, flow cytometry and western blot analysis, the molecular basis for the effects of staurosporine in combination with the irradiation of leukemia cells was investigated. RESULTS: Our results indicated that combined treatment led to an increased apoptotic cell death in U937 cells, which is correlated with the phosphorylation of the V-Jun sarcoma virus 17 oncogene homolog (c-JUN) NH(2)-terminal kinase protein (JNK), the activation of caspases, the increase in B cell leukemia/lymphoma 2 (Bcl-2) associated X protein (Bax), the decrease in Bcl xL protein (Bcl-XL) levels, the loss of mitochondria membrane potential and the release of cytochrome c. CONCLUSIONS: Abrogation of the G2 checkpoint should be an effective strategy against p53-deficient leukemia cells to irradiation-induced cell killing. ------>tmu_sno=None ------>sno=14226 ------>authors2=Chia-Hsin Chen ------>authors3=Sheng-Yow Ho ------>authors4=Yuan-Soon Ho ------>authors5=Rong-Jane Chen ------>authors6=Ying-Jan Wang ------>authors6_c= ------>authors=How-Ran Guo ------>delete_flag=0 ------>SCI_JNo=None ------>authors2_c= ------>publish_area=0 ------>updateTitle=Staurosporine modulates radiosensitivity and radiation-induced apoptosis in U937 cells. ------>language=2 ------>check_flag=None ------>submit_date=None ------>country=None ------>no=2 ------>patent_SDate=None ------>update_bywho=None ------>publish_year=2006 ------>submit_flag=None ------>publish_month=2 |