Taipei Medical University

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Chang SF
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------>insert_date=20061201
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------>journal_name=J. Nat. Prod.
------>paper_name=Transformation of steviol-16alpha,17-epoxide by Streptomyces griseus and Cunninghamella bainieri
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------>fullAbstract=Eight new ent-beyerane metabolites, 5-8, 12, and 14-16, and four new ent-kaurane metabolites, 3, 10, 11, and 13, together with two known metabolites, 4 and 9, were isolated from the microbial transformations of steviol-16alpha,17-epoxide using Streptomyces griseus ATCC 10137 and Cunninghamella bainieri ATCC 9244. The structures of the metabolites were characterized by IR, HRFABMS, and 1D and 2D NMR data. In addition, a GRE (glucocorticoid response element)-mediated luciferase reporter assay was used to initially screen for the biological activity of the 11 metabolites and stevioside. Steviol (1), steviol-16alpha,17-epoxide (2), ent-11alpha,13,16alpha,17-tetrahydroxykauran-19-oic acid (3), ent-17-hydroxy-16-ketobeyeran-19-oic acid (4), ent-9alpha,13-dihydroxy-16beta,17-epoxykauran-19-oic acid (10), ent-9alpha,17-dihydroxy-16-ketobeyeran-19-oic acid (12), ent-1beta,17-dihydroxy-16-ketobeyeran-19-oic acid (14), and stevioside showed significant effects; in particular, stevioside showed almost equal potency as dexamethasone.
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------>authors2=Yang LM
------>authors3=Hsu FL
------>authors4=Hsu JY
------>authors5=Liaw JH
------>authors6=Lin SJ
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------>authors=Chang SF
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------>updateTitle=Transformation of steviol-16alpha,17-epoxide by Streptomyces griseus and Cunninghamella bainieri.
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------>publish_year=2006
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A B C D E F G H I J K L M N O P Q R S T U V W X Y Z