Chang SF |
------>authors3_c= ------>paper_class1=1 ------>Impact_Factor=2.267 ------>paper_class3=2 ------>paper_class2=1 ------>vol=69 ------>confirm_bywho=kyhsu ------>insert_bywho=shwu-lin ------>Jurnal_Rank=13.6 ------>authors4_c= ------>comm_author=1 ------>patent_EDate=None ------>authors5_c= ------>publish_day=27 ------>paper_class2Letter=None ------>page2=1455 ------>medlineContent= ------>unit=G0100 ------>insert_date=20061201 ------>iam=7 ------>update_date=None ------>author=??? ------>change_event=4 ------>ISSN= ------>authors_c= ------>score=500 ------>journal_name=J. Nat. Prod. ------>paper_name=Transformation of steviol-16alpha,17-epoxide by Streptomyces griseus and Cunninghamella bainieri ------>confirm_date=20061229 ------>tch_id=076002 ------>pmid=17067160 ------>page1=1450 ------>fullAbstract=Eight new ent-beyerane metabolites, 5-8, 12, and 14-16, and four new ent-kaurane metabolites, 3, 10, 11, and 13, together with two known metabolites, 4 and 9, were isolated from the microbial transformations of steviol-16alpha,17-epoxide using Streptomyces griseus ATCC 10137 and Cunninghamella bainieri ATCC 9244. The structures of the metabolites were characterized by IR, HRFABMS, and 1D and 2D NMR data. In addition, a GRE (glucocorticoid response element)-mediated luciferase reporter assay was used to initially screen for the biological activity of the 11 metabolites and stevioside. Steviol (1), steviol-16alpha,17-epoxide (2), ent-11alpha,13,16alpha,17-tetrahydroxykauran-19-oic acid (3), ent-17-hydroxy-16-ketobeyeran-19-oic acid (4), ent-9alpha,13-dihydroxy-16beta,17-epoxykauran-19-oic acid (10), ent-9alpha,17-dihydroxy-16-ketobeyeran-19-oic acid (12), ent-1beta,17-dihydroxy-16-ketobeyeran-19-oic acid (14), and stevioside showed significant effects; in particular, stevioside showed almost equal potency as dexamethasone. ------>tmu_sno=None ------>sno=14285 ------>authors2=Yang LM ------>authors3=Hsu FL ------>authors4=Hsu JY ------>authors5=Liaw JH ------>authors6=Lin SJ ------>authors6_c= ------>authors=Chang SF ------>delete_flag=0 ------>SCI_JNo=None ------>authors2_c= ------>publish_area=0 ------>updateTitle=Transformation of steviol-16alpha,17-epoxide by Streptomyces griseus and Cunninghamella bainieri. ------>language=2 ------>check_flag=None ------>submit_date=None ------>country=None ------>no= ------>patent_SDate=None ------>update_bywho=None ------>publish_year=2006 ------>submit_flag=None ------>publish_month=10 |