Taipei Medical University

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Shieh Ying-Hua
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------>paper_name=Apotosi?Immuno-modulatory effect
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------>fullAbstract=Fasciola hepatica is a helminth pathogen that drives Th2/Treg immune responses in its mammalian host. The parasite releases a large number of molecules that are critical to inducing this type of immune response. Here we have selected recombinant forms of two major F. hepatica secreted molecules, the protease cathepsin L (rFhCL1) and anti-oxidant, sigma class glutathione transferase (rFhGST-si), to examine their interactions with dendritic cells (DCs). Despite enzymatic and functional differences between these molecules, both induced IL-6, IL-12p40 and MIP-2 secretion from DCs and enhanced CD40 expression. While this induction was mediated by toll-like receptor 4 (TLR4), their subsequent intracellular signalling pathways differed; rFhCL1 signalled through p38 and rFhGST-si mediated its effect via JNK, p38, p-NF-kappaBp65 and IRF5. Neither rFhCL1 nor rFhGST-si enhanced DC phagocytosis or induced Th2 immune responses in vivo. However, DCs matured in the presence of either enzyme attenuated IL-17 production from OVA-specific T-cells in vivo. In addition, DCs exposed to either antigen secreted reduced levels of IL-23. Therefore, both F. hepatica FhCL1 and FhGST-si modulate host immunity by suppressing responses associated with chronic inflammation - an immune modulatory mechanism that may benefit the parasites survival within the host.
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------>authors=Shieh Ying-Hua
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------>updateTitle=Major secretory antigens of the helminth Fasciola hepatica activate a suppressive dendritic cell phenotype that attenuates Th17 cells but fails to activate Th2 immune responses.
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A B C D E F G H I J K L M N O P Q R S T U V W X Y Z