Huang YK |
------>authors3_c= ------>paper_class1=1 ------>Impact_Factor=3.148 ------>paper_class3=2 ------>paper_class2=1 ------>vol=218 ------>confirm_bywho=hychiou ------>insert_bywho=ymhsueh ------>Jurnal_Rank=12.0 ------>authors4_c= ------>comm_author=1 ------>patent_EDate=None ------>authors5_c= ------>publish_day=1 ------>paper_class2Letter=None ------>page2=142 ------>medlineContent= ------>unit=E0108 ------>insert_date=20070130 ------>iam=7 ------>update_date=None ------>author=??? ------>change_event=4 ------>ISSN= ------>authors_c= ------>score=500 ------>journal_name=Toxicol Appl Pharmacol ------>paper_name=Arsenic Methylation Capability and Hypertension Risk in Subjects Living in Arseniasis-Hyperendemic Areas in Southwestern Taiwan ------>confirm_date=20070506 ------>tch_id=073001 ------>pmid=17173945 ------>page1=135 ------>fullAbstract=BACKGROUND: Cumulative arsenic exposure (CAE) from drinking water has been shown to be associated with hypertension in a dose-response pattern. This study further explored the association between arsenic methylation capability and hypertension risk among residents of arseniasis-hyperendemic areas in Taiwan considering the effect of CAE and other potential confounders. METHOD: There were 871 subjects (488 women and 383 men) and among them 372 were diagnosed as having hypertension based on a positive history or measured systolic blood pressure >or=140 mm Hg and/or diastolic blood pressure >or=90 mm Hg. Urinary arsenic species were determined by high-performance liquid chromatography-hydride generator and atomic absorption spectrometry. Primary arsenic methylation index [PMI, defined as monomethylarsonic acid (MMA(V)) divided by (As(III)+As(V))] and secondary arsenic methylation index (SMI, defined as dimethylarsinic acid divided by MMA(V)) were used as indicators for arsenic methylation capability. RESULTS: The level of urinary arsenic was still significantly correlated with cumulative arsenic exposure (CAE) calculated from a questionnaire interview (p=0.02) even after the residents stopped drinking the artesian well water for 2-3 decades. Hypertensive subjects had higher percentages of MMA(V) and lower SMI than subjects without hypertension. However, subjects having CAE >0 mg/L-year had higher hypertension risk than those who had CAE=0 mg/L-year disregard a high or low methylation index. CONCLUSION: Inefficient arsenic methylation ability may be related with hypertension risk. ------>tmu_sno=None ------>sno=14698 ------>authors2=Tseng CH ------>authors3=Huang YL ------>authors4=Yang MH ------>authors5=Chen CJ ------>authors6=Hsueh YM ------>authors6_c= ------>authors=Huang YK ------>delete_flag=0 ------>SCI_JNo=None ------>authors2_c= ------>publish_area=0 ------>updateTitle=Arsenic methylation capability and hypertension risk in subjects living in arseniasis-hyperendemic areas in southwestern Taiwan. ------>language=2 ------>check_flag=None ------>submit_date=None ------>country=None ------>no= ------>patent_SDate=None ------>update_bywho=None ------>publish_year=2007 ------>submit_flag=None ------>publish_month=1 |