| Lin MT |
------>authors3_c= ------>paper_class1=1 ------>Impact_Factor=2.170 ------>paper_class3=2 ------>paper_class2=2 ------>vol=60 ------>confirm_bywho=jschu ------>insert_bywho=sschuang ------>Jurnal_Rank=33.3 ------>authors4_c= ------>comm_author=1 ------>patent_EDate=None ------>authors5_c= ------>publish_day=1 ------>paper_class2Letter=None ------>page2=103 ------>medlineContent= ------>unit=E0102 ------>insert_date=20070421 ------>iam=7 ------>update_date=None ------>author=??? ------>change_event=4 ------>ISSN= ------>authors_c= ------>score=494 ------>journal_name=J Clin Pathol ------>paper_name=Massive expansion of EBV+ monoclonal T-cells with CD5 down-regulation in EBV-associated hemophagocytic lymphohistiocytosis. ------>confirm_date=20070421 ------>tch_id=094004 ------>pmid=17213357 ------>page1=101 ------>fullAbstract=Haemophagocytic lymphohistiocytosis (HLH) comprises primary and secondary forms; the secondary form is most commonly triggered by the Epstein-Barr virus (EBV; EBV-HLH). Patients with EBV-HLH usually exhibit oligoclonal or monoclonal T cell proliferation, which may mimic T cell lymphoproliferative disorder (T-LPD). This article reports on EBV-HLH in a 17-month-old girl with an extreme surge of reactive T lymphocytosis (absolute count 167x10(9)/l) with CD5 down regulation. Bone marrow aspirate and trephine contained florid haemophagocytosis and massive infiltration of CD3+ Epstein-Barr virus-encoded RNA+ lymphocytes, as seen by double labelling. These lymphocytes were monoclonal for EBV and T cell receptor gamma chain gene rearrangement. The patient responded dramatically to intravenous immunoglobulin, interferon alpha2b, ganciclovir and prednisolone, suggesting restoration of her immune system and eradication of the clonal T cells through these immunoregulatory agents. Thus, careful clinicopathological correlation is warranted in the interpretation of immunophenotyping and clonality data in T cell proliferation in association with EBV-HLH to avoid erroneous diagnosis of T-LPD. ------>tmu_sno=None ------>sno=15132 ------>authors2=Chang HM ------>authors3=Huang CJ ------>authors4=Chen WL ------>authors5=Lin CY ------>authors6=Lin CY, Chuang SS ------>authors6_c= ------>authors=Lin MT ------>delete_flag=0 ------>SCI_JNo=None ------>authors2_c= ------>publish_area=0 ------>updateTitle=Massive expansion of EBV+ monoclonal T cells with CD5 down regulation in EBV-associated haemophagocytic lymphohistiocytosis. ------>language=2 ------>check_flag=None ------>submit_date=None ------>country=None ------>no= ------>patent_SDate=None ------>update_bywho=None ------>publish_year=2007 ------>submit_flag=None ------>publish_month=1 |