Taipei Medical University

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Liu SY
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------>ISSN=0929-6646
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------>journal_name=Journal of the Formosan Medical Association
------>paper_name=Areca quid chewing enhances the expression of salivary matrix metalloproteinase-9.
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------>fullAbstract=BACKGROUND AND PURPOSE: The effects of areca quid (AQ) consumption on salivary matrix metalloproteinases (MMPs) which may participate in tumor invasion and metastasis remains unclear. This study assessed the change in salivary MMP-9 protein levels 2 hours after 5-minute AQ chewing stimulation (AQCS) in non-AQ users and the expression profile of this proteinase in saliva and tumor specimens of oral squamous cell carcinoma (OSCC) patients with a history of AQ use. METHODS: MMP-9 transcript was analyzed by reverse transcription-polymerase chain reaction. MMP-9 protein level was measured by both Western blot and gelatin zymography. RESULTS: The protein level of salivary MMP-9 was 3.1- to 8.9-fold enhanced 2 h after AQCS in 3 healthy volunteers as revealed by Western blot and zymography. As a control, gum chewing did not significantly change salivary MMP-9 protein level. Expression of MMP-9 transcript was found in 25 of 28 OSCC specimens and significantly correlated with cervical lymph node metastasis (p = 0.037). All of the 8 tested OSCC tissue homogenate samples available and all 12 saliva samples from 12 oral tumor outpatients were positive for MMP-9 protein. CONCLUSIONS: Elevation of MMP-9 may be one of the net effects of AQCS in vivo, which may play a role in the pathogenesis of oral mucosal lesions. Furthermore, the association of MMP-9 expression with neck-lymph-node metastasis may imply a significant role of MMP-9 in the progression of OSCC among patients with a history of AQ use in Taiwan.
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------>authors2=Lin MH
------>authors3=Yang SC
------>authors4=Yen CY
------>authors5=Chiang WF
------>authors6=Kuo YY,Lee CH,Liu CY
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------>authors=Liu SY
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------>updateTitle=Areca quid chewing enhances the expression of salivary matrix metalloproteinase-9.
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------>no=2
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------>publish_year=2005
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------>publish_month=2
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z