| Que J |
------>authors3_c= ------>paper_class1=1 ------>Impact_Factor=None ------>paper_class3=1 ------>paper_class2=1 ------>vol=43 ------>confirm_bywho=None ------>insert_bywho=syliu ------>Jurnal_Rank=None ------>authors4_c= ------>comm_author= ------>patent_EDate=None ------>authors5_c= ------>publish_day=1 ------>paper_class2Letter=None ------>page2=16 ------>medlineContent= ------>unit=000 ------>insert_date=20070426 ------>iam=2 ------>update_date=None ------>author=??? ------>change_event=1 ------>ISSN=0254-1319 ------>authors_c= ------>score=500 ------>journal_name=Acta Anaesthesiol Taiwanica ------>paper_name=A novel long-acting analgesic: buprenorphine palmitate in rats ------>confirm_date=None ------>tch_id=078008 ------>pmid=15868999 ------>page1=11 ------>fullAbstract=BACKGROUND: A long-acting analgesic may be particularly desirable in patients with long-lasting pain. In order to provide a long-acting analgesic effect, a novel buprenorphine ester, buprenorphine palmitate, was synthesized in our laboratory. The aim of the study was to evaluate whether the ester had a long-lasting effect. METHODS: The antinociceptive effects (dose-range studies) of buprenorphine HCl and buprenorphine palmitate were evaluated using the plantar test in Sprague-Dawley rats. RESULTS: We found that intramuscular injection of buprenorphine HCl 0.05, 0.1 and 1 micromol/kg in rats produced dose-related antinociceptive effects of 2, 3, and 4 h, respectively. Intramuscular injection of buprenorphine palmitate 1, 5, and 10 micromol/kg also produced dose-related antinociceptive effects of 72, 76 and 78 h, respectively. On an equimolar basis of 1 micromol/kg, the durations of action of intramuscular buprenorphine HCl and buprenorphine palmitate were 4 and 72 h, respectively. CONCLUSIONS: Intramuscular injection of buprenorphine palmitate in rats produced a long-lasting antinociceptive effect which was much longer (18-fold) than did intramuscular buprenorphine HCl. ------>tmu_sno=None ------>sno=15175 ------>authors2=Lin LC ------>authors3=Liu SY ------>authors4=Ho ST ------>authors5=Wang JJ ------>authors6= ------>authors6_c= ------>authors=Que J ------>delete_flag=0 ------>SCI_JNo=None ------>authors2_c= ------>publish_area=0 ------>updateTitle=A novel long-acting analgesic: buprenorphine palmitate in rats. ------>language=2 ------>check_flag=None ------>submit_date=None ------>country=NULL ------>no=1 ------>patent_SDate=None ------>update_bywho=None ------>publish_year=2005 ------>submit_flag=None ------>publish_month=3 |