Lin MH |
------>authors3_c= ------>paper_class1=1 ------>Impact_Factor=2.266 ------>paper_class3=2 ------>paper_class2=1 ------>vol=42 ------>confirm_bywho=seanlee ------>insert_bywho=syliu ------>Jurnal_Rank=8.2 ------>authors4_c= ------>comm_author= ------>patent_EDate=None ------>authors5_c= ------>publish_day=1 ------>paper_class2Letter=None ------>page2=913 ------>medlineContent= ------>unit=F0100 ------>insert_date=20070426 ------>iam=2 ------>update_date=None ------>author=??? ------>change_event=4 ------>ISSN=1368-8375 ------>authors_c= ------>score=500 ------>journal_name=Oral Oncology ------>paper_name=Functional role of matrix metalloproteinase-28 in the oral squamous cell carcinoma. ------>confirm_date=20070426 ------>tch_id=078008 ------>pmid=16730219 ------>page1=907 ------>fullAbstract=The newly identified MMP-28 has been shown to be expressed in several types of carcinomas, however, its functional role in transformation events is unknown. This study was to assess whether this proteinase plays a role in oral tumor malignancy. By using RT-PCR, we found that expression of MMP-28 was significantly higher in 92 oral squamous cell carcinomas (OSCCs) (52/92, 56.5%) than in seven oral premalignant lesions (OPMLs) (0/7, 0%) (P=0.004). No statistically significant correlation was found between MMP-28 expression and tumor stage, thickness, size, and metastasis. Both mRNA and protein of MMP-28 were preferentially concentrated in OSCC specimens than in neighboring tissues as analyzed by semi-quantitative RT-PCR (P=0.015) and immunohistochemistry, respectively. Transfection of OSCC and esophageal carcinoma cell lines with MMP-28 antisense oligodeoxynucleotide (AODN) resulted in the reduced secretion of MMP-28 protein and the ability of colony formation in soft agar without affecting cell growth. Our findings show the close correlation between MMP-28 and OSCC, and support a role for MMP-28 in the anchorage-independent growth of both OSCC and esophageal carcinomas. ------>tmu_sno=None ------>sno=15183 ------>authors2=Liu SY ------>authors3=Liu YC ------>authors4= ------>authors5= ------>authors6= ------>authors6_c= ------>authors=Lin MH ------>delete_flag=0 ------>SCI_JNo=None ------>authors2_c= ------>publish_area=0 ------>updateTitle=Functional role of matrix metalloproteinase-28 in the oral squamous cell carcinoma. ------>language=2 ------>check_flag=None ------>submit_date=None ------>country=None ------>no=9 ------>patent_SDate=None ------>update_bywho=None ------>publish_year=2006 ------>submit_flag=None ------>publish_month=10 |