Taipei Medical University

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Liu SY
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------>ISSN=0904-2512
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------>journal_name=Journal of Oral Pathology & Medicine
------>paper_name=Requirement of MMP-3 in anchorage-independent growth of oral squamous cell carcinomas
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------>fullAbstract=BACKGROUND: Matrix metalloproteinase-3 (MMP-3) is expressed in various carcinomas; however, its function is not clearly established. This study was to assess its possible role in oral squamous cell carcinomas (OSCCs). MATERIALS AND METHODS: Specimens of seven oral pre-malignant lesions (OPMLs) and 92 OSCCs were subjected to MMP-3 detection by RT-PCR and Western blot. Antisense oligodeoxynucleotides (AODNs) of MMP-3 were used to transfect OSCC (OECM-1 and SCC-9) and esophageal carcinoma (CE81T/VGH) cell lines, and their growth was subsequently analyzed by XTT and soft-agar colony assay. RESULTS: MMP-3 transcript was preferentially expressed in OSCCs (71 of 92, 77%) than in OPMLs (two of seven, 29%; P = 0.012). Both MMP-3 transcript and protein levels were significantly higher in OSCC masses than in neighboring tissues (P < 0.0001 and P = 0.04, respectively). Growth of the three cell lines was not affected, while the colony numbers of OECM-1 and CE81T/VGH were significantly reduced by the transfection of MMP-3 AODNs (P = 0.002 and P = 0.004, respectively). SCC-9 did not form colonies in soft-agar/medium. CONCLUSIONS: MMP-3 function may be required in most OSCCs, and it may support the anchorage-independent growth of both OSCC and esophageal carcinoma.
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------>authors2=Liu YC
------>authors3=Huang WT
------>authors4=Huang GC
------>authors5=Hsiao JS
------>authors6=Chiang WF,Lee CH,Lin MH
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------>authors=Liu SY
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------>updateTitle=Requirement of MMP-3 in anchorage-independent growth of oral squamous cell carcinomas.
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------>no=7
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------>publish_year=2007
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------>publish_month=8
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z