| Chiang WF |
------>authors3_c= ------>paper_class1=1 ------>Impact_Factor=2.266 ------>paper_class3=2 ------>paper_class2=1 ------>vol=44 ------>confirm_bywho=seanlee ------>insert_bywho=syliu ------>Jurnal_Rank=8.2 ------>authors4_c= ------>comm_author= ------>patent_EDate=None ------>authors5_c= ------>publish_day=1 ------>paper_class2Letter=None ------>page2=334 ------>medlineContent= ------>unit=F0100 ------>insert_date=20070426 ------>iam=2 ------>update_date=None ------>author=??? ------>change_event=4 ------>ISSN=1368-8375 ------>authors_c= ------>score=500 ------>journal_name=Oral Oncology ------>paper_name=Overexpression of galectin-1 at the tumor invasion front is associated with poor prognosis in early-stage oral squamous cell carcinoma ------>confirm_date=20080428 ------>tch_id=078008 ------>pmid=17588803 ------>page1=325 ------>fullAbstract=Metastasis is a final and eventually fatal step in the progression of oral squamous cell carcinoma (OSCC) and typically accompanies a large primary tumor. Metastasis may also present from a small primary tumor and progress rapidly; therefore, early diagnosis is important for patients with small primary tumors. Galectin-1 is one significantly upregulated tumor-associated protein in many neoplasms. To determine the clinical significance of galectin-1, we analyzed its expression in clinical samples by immunohistochemistry and reverse transcription-quantitative polymerase chain reaction assay. Galectin-1 protein was significantly overexpressed in the tumor-associated stroma as well as the invasion front during early oral carcinogenesis (P<0.05). During the metastatic stage, the only significant immunoreactivity was at the tumor invasion front (P<0.05). Although galectin-1 mRNA was not significantly upregulated in the whole cancerous tissue, it was upregulated in stromal parts during early-stage OSCC and in epithelial parts at the metastatic stage. Survival analysis and a Cox~s proportional hazards model showed that synchronous upregulation of galectin-1 protein and mRNA was correlated with worse disease-free survival in early-stage OSCC (P=0.024 and P=0.047, respectively). Our findings suggest that galectin-1 upregulation at the tumor invasion front might be a predictor of early metastasis in oral carcinogenesis. ------>tmu_sno=None ------>sno=15205 ------>authors2=Liu SY ------>authors3=Fang LN ------>authors4=Lin CN ------>authors5=Wu MH ------>authors6=Chen YC,Jin YT ------>authors6_c= ------>authors=Chiang WF ------>delete_flag=0 ------>SCI_JNo=None ------>authors2_c= ------>publish_area=0 ------>updateTitle=Overexpression of galectin-1 at the tumor invasion front is associated with poor prognosis in early-stage oral squamous cell carcinoma. ------>language=2 ------>check_flag=None ------>submit_date=None ------>country=None ------>no=4 ------>patent_SDate=None ------>update_bywho=None ------>publish_year=2007 ------>submit_flag=None ------>publish_month=4 |