| Yang S |
------>authors3_c= ------>paper_class1=1 ------>Impact_Factor=3.592 ------>paper_class3=2 ------>paper_class2=1 ------>vol=177 ------>confirm_bywho=kueiru ------>insert_bywho=ptsai ------>Jurnal_Rank=13.7 ------>authors4_c= ------>comm_author= ------>patent_EDate=None ------>authors5_c= ------>publish_day=1 ------>paper_class2Letter=None ------>page2=1933 ------>medlineContent= ------>unit=H0200 ------>insert_date=20070426 ------>iam=4 ------>update_date=None ------>author=??? ------>change_event=4 ------>ISSN= ------>authors_c= ------>score=500 ------>journal_name=Journal of Urology ------>paper_name=The protective role of heme oxygenase-1 induction on testicular tissues after testicular torsion and detorsion ------>confirm_date=20070427 ------>tch_id=091090 ------>pmid=17437850 ------>page1=1928 ------>fullAbstract=PURPOSE: Testicular torsion-detorsion has been identified as an ischemia-reperfusion type of injury. We elucidated the protective role of heme oxygenase-1 super induction on testicular torsion-detorsion injury. MATERIALS AND METHODS: Adult male Sprague-Dawley rats were randomly allocated to undergo testicular torsion-detorsion, immediately followed by injection of normal saline, the heme oxygenase-1 inducer hemin or hemin plus the heme oxygenase-1 inhibitor tin protoporphyrin. Another set of rats that underwent sham operation, immediately followed by injection of normal saline, hemin or hemin plus tin protoporphyrin, served as controls. Testes were harvested 4 and 24 hours after detorsion, respectively, in the experimental groups or at comparable time points in the control groups. RESULTS: Histological evaluation confirmed that torsion-detorsion caused significant testicular tissue injury. Torsion-detorsion also caused significant increases in the testicular levels of nitric oxide, malondialdehyde, myeloperoxidase activity and heme oxygenase-1. The heme oxygenase-1 inducer hemin significantly enhanced the heme oxygenase-1 expression induced by torsion-detorsion and in turn attenuated testicular injury, and increases in nitric oxide, malondialdehyde and myeloperoxidase activity. In addition, the protective effects of hemin were significantly offset by the heme oxygenase-1 inhibitor tin protoporphyrin. CONCLUSIONS: Super induction of heme oxygenase-1 protects testes from torsion-detorsion injury. ------>tmu_sno=None ------>sno=15221 ------>authors2=Shih HJ ------>authors3=CHow YC ------>authors4=Tsai PS ------>authors5=Wang TY ------>authors6=Wang PS, Huang CJ ------>authors6_c= ------>authors=Yang S ------>delete_flag=0 ------>SCI_JNo=None ------>authors2_c= ------>publish_area=0 ------>updateTitle=The protective role of heme oxygenase-1 induction on testicular tissues after testicular torsion and detorsion. ------>language=2 ------>check_flag=None ------>submit_date=None ------>country=None ------>no=5 ------>patent_SDate=None ------>update_bywho=None ------>publish_year=2007 ------>submit_flag=None ------>publish_month=5 |