| Yeh SW |
------>authors3_c= ------>paper_class1=1 ------>Impact_Factor=2.182 ------>paper_class3=2 ------>paper_class2=3 ------>vol=6 ------>confirm_bywho=None ------>insert_bywho=yehsw ------>Jurnal_Rank=23.1 ------>authors4_c= ------>comm_author= ------>patent_EDate=None ------>authors5_c= ------>publish_day=1 ------>paper_class2Letter=None ------>page2=342 ------>medlineContent= ------>unit=000 ------>insert_date=20070429 ------>iam=1 ------>update_date=None ------>author=??? ------>change_event=2 ------>ISSN=1175-0561 ------>authors_c= ------>score=500 ------>journal_name=Am J Clin Dermatol ------>paper_name=Treatment of pemphigus vulgaris: current and emerging options ------>confirm_date=None ------>tch_id=095046 ------>pmid=16252932 ------>page1=327 ------>fullAbstract=BACKGROUND: Pemphigus vulgaris is a rare, chronic, autoimmune mucocutaneous blistering disease. The disease can progress to involve the skin and multiple mucosae. Pemphigus vulgaris can be associated with a high morbidity and significant mortality rate. Treatment of the condition can be challenging. Conventional therapy primarily consists of systemic corticosteroids and immunosuppressant agents. In some patients with pemphigus vulgaris, these agents fail to provide an effective clinical response or have significant adverse effects. METHODS: We evaluated data on 792 patients with pemphigus vulgaris retrieved from PubMed, covering the period 1973-2004. Only patients reported in the English literature were included in this review. Recently, several new therapeutic agents and treatment modalities have been described for the treatment of patients with pemphigus vulgaris. Some therapeutic agents that were used in the past and abandoned have recently regained favor. This review focuses on the therapeutic uses of dapsone, methotrexate, mycophenolate mofetil, chlorambucil, dexamethasone-cyclophosphamide pulse therapy, immunoablative therapy with cyclophosphamide, plasmapheresis, and extracorporeal photochemotherapy. Newer agents, such as intravenous immunoglobulin (IVIg) therapy and rituximab (an anti-CD20 chimeric monoclonal antibody), are also discussed. RESULTS AND CONCLUSIONS: Among the oral agents, dapsone may be considered a first-line agent. This is primarily because the risk of potentially fatal adverse effects with this drug is lower than that associated with other available chemotherapeutic agents. In patients who are refractory to oral agents, alternative treatments have been used to prevent further disease progression. Recently, the use of IVIg therapy, with a defined protocol, has been reported to be beneficial. This therapy is promising since it may allow for discontinuation of all other therapies and is safe. The adverse effects from IVIg therapy are minimal. Furthermore, compared with other therapies, it provides a better quality of life. ------>tmu_sno=None ------>sno=15246 ------>authors2=Sami N ------>authors3=Ahmed AR ------>authors4= ------>authors5= ------>authors6= ------>authors6_c= ------>authors=Yeh SW ------>delete_flag=0 ------>SCI_JNo=None ------>authors2_c= ------>publish_area=0 ------>updateTitle=Treatment of pemphigus vulgaris: current and emerging options. ------>language=2 ------>check_flag=None ------>submit_date=None ------>country=None ------>no=5 ------>patent_SDate=None ------>update_bywho=None ------>publish_year=2005 ------>submit_flag=None ------>publish_month=6 |