| Armstrong AW |
------>authors3_c= ------>paper_class1=1 ------>Impact_Factor=1.333 ------>paper_class3=2 ------>paper_class2=2 ------>vol=31 ------>confirm_bywho=None ------>insert_bywho=yehsw ------>Jurnal_Rank=48.7 ------>authors4_c= ------>comm_author= ------>patent_EDate=None ------>authors5_c= ------>publish_day=1 ------>paper_class2Letter=None ------>page2=397 ------>medlineContent= ------>unit=000 ------>insert_date=20070429 ------>iam=3 ------>update_date=None ------>author=??? ------>change_event=1 ------>ISSN=0303-6987 ------>authors_c= ------>score=500 ------>journal_name=J Cutan Pathol ------>paper_name=Vancomycin-induced linear IgA disease manifesting as bullous erythema multiforme ------>confirm_date=None ------>tch_id=095046 ------>pmid=15059226 ------>page1=393 ------>fullAbstract=BACKGROUND: Vancomycin-induced linear immunoglobulin A (IgA) disease, an autoimmune, blistering disease in response to vancomycin administration, is characterized by a subepidermal, vesiculobullous eruption and linear IgA deposition along the basement membrane zone on direct immunofluorescence. CASE REPORT: We report the case of an 81-year-old man treated with vancomycin who developed diffuse erythema multiforme and tense bullae involving the palmoplantar surfaces. Discontinuation of vancomycin therapy resulted in complete resolution of this patient~s cutaneous eruption. RESULTS: Biopsy of a representative skin lesion demonstrated lichenoid interface dermatitis with focal subepidermal clefting, dyskeratosis, and prominent eosinophils. Direct immunofluorescence showed linear basement membrane staining with immunoreactants to IgA; indirect immunofluorescence demonstrated the presence of circulating IgG antibodies binding in an intercellular pattern. Immunoprecipitation studies using the patient~s serum revealed 210, 130, and 83 kDa target antigens. CONCLUSIONS: Presenting with an initial clinical picture suggestive of bullous erythema multiforme, this patient~s subsequent clinical course and direct immunofluorescence confirm the diagnosis of linear IgA bullous disease (LABD). His indirect immunofluorescence findings and immunoprecipitation results suggest that circulating non-IgA antibodies may represent a newly recognized immunopathologic feature of vancomycin-induced linear IgA disease, underscoring the variable and unpredictable manifestations of this drug-induced cutaneous disease. ------>tmu_sno=None ------>sno=15248 ------>authors2=Fazeli A ------>authors3=Yeh SW ------>authors4=Mackool BT ------>authors5=Liu V ------>authors6= ------>authors6_c= ------>authors=Armstrong AW ------>delete_flag=0 ------>SCI_JNo=None ------>authors2_c= ------>publish_area=0 ------>updateTitle=Vancomycin-induced linear IgA disease manifesting as bullous erythema multiforme. ------>language=2 ------>check_flag=None ------>submit_date=None ------>country=None ------>no=5 ------>patent_SDate=None ------>update_bywho=None ------>publish_year=2004 ------>submit_flag=None ------>publish_month=5 |