Taipei Medical University

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Chang JY
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------>journal_name=J. Med. Chem
------>paper_name=7-Aroyl-aminoindoline-1-sulfonamide as a Novel Class Antimitotic Agent
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------>fullAbstract=A novel series of 7-aroyl-aminoindoline-1-benzenesulfonamides showed excellent activity as inhibitors of tubulin polymerization through binding with the colchicine binding site of microtubules. Compound 15 and 16 display IC50 values of 1.1 and 1.2 microM, respectively. Compound 15 inhibited the human cancer cell growth of KB, MKN45, H460, HT29, and TSGH, as well as one human-resistant cancer line of KB-vin 10, with an IC50 of 9.6, 8.8, 9.4, 8.6, 10.8, and 8.9 nM, respectively.
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------>authors2=Hsieh HP
------>authors3=Chang CY
------>authors4=Hsu KS
------>authors5=Chiang YF
------>authors6=Chen CM, Kuo CC , Liou JP
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------>authors=Chang JY
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------>updateTitle=7-Aroyl-aminoindoline-1-sulfonamides as a novel class of potent antitubulin agents.
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------>publish_year=2006
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A B C D E F G H I J K L M N O P Q R S T U V W X Y Z