| Liang CL |
------>authors3_c= ------>paper_class1=1 ------>Impact_Factor=1.978 ------>paper_class3=2 ------>paper_class2=1 ------>vol=52 ------>confirm_bywho=shtsai ------>insert_bywho=kshung ------>Jurnal_Rank=61.3 ------>authors4_c= ------>comm_author= ------>patent_EDate=None ------>authors5_c= ------>publish_day=1 ------>paper_class2Letter=None ------>page2=377 ------>medlineContent= ------>unit=J0600 ------>insert_date=20070501 ------>iam=2 ------>update_date=None ------>author=??? ------>change_event=4 ------>ISSN= ------>authors_c= ------>score=500 ------>journal_name=Journal of Human Genetics ------>paper_name=Systematic Assessment of the Tagging Polymorphisms of the COL1A1 Gene for High Myopia ------>confirm_date=20070501 ------>tch_id=095047 ------>pmid=17273809 ------>page1=374 ------>fullAbstract=Reduced scleral collagen accumulation has been found in the development of myopia. Single nucleotide polymorphisms (SNPs) at the type I collagen alpha-1 gene (COL1A1) may cause different susceptibilities to myopia. We conducted a case-control study to systematically examine COL1A1 as a candidate gene for high myopia. A case was defined as spherical refraction <or=-6 D and control >or=-1.5 D. The study comprised 471 cases and 623 controls, and ten tagging SNPs were genotyped. None of the SNPs reached the significant level of 0.05. Subset analysis on cases with a strong family history did not demonstrate significant results. We could not find an interaction between gene and near work. Exploratory analyses by changing the cutoff values to re-define cases and controls did not improve the results. Haplotype analysis did not yield significant association with myopia. This study failed to demonstrate COL1A1 as a significant risk factor for high myopia. ------>tmu_sno=None ------>sno=15352 ------>authors2=Hung KS ------>authors3=Tsai YY ------>authors4=Chang W ------>authors5=Wang HS ------>authors6=Juo SHH ------>authors6_c= ------>authors=Liang CL ------>delete_flag=0 ------>SCI_JNo=None ------>authors2_c= ------>publish_area=0 ------>updateTitle=Systematic assessment of the tagging polymorphisms of the COL1A1 gene for high myopia. ------>language=2 ------>check_flag=None ------>submit_date=None ------>country=None ------>no=4 ------>patent_SDate=None ------>update_bywho=None ------>publish_year=2007 ------>submit_flag=None ------>publish_month=2 |