| Hung KS |
------>authors3_c= ------>paper_class1=1 ------>Impact_Factor=3.000 ------>paper_class3=2 ------>paper_class2=1 ------>vol=336 ------>confirm_bywho=None ------>insert_bywho=kshung ------>Jurnal_Rank=32.3 ------>authors4_c= ------>comm_author= ------>patent_EDate=None ------>authors5_c= ------>publish_day=1 ------>paper_class2Letter=None ------>page2=331 ------>medlineContent= ------>unit=000 ------>insert_date=20070501 ------>iam=1 ------>update_date=None ------>author=??? ------>change_event=1 ------>ISSN= ------>authors_c= ------>score=500 ------>journal_name=Biochem Biophys Res Commun ------>paper_name=Interleukin-10 gene therapy reverses thioacetamide-induced liver fibrosis in mice ------>confirm_date=None ------>tch_id=095047 ------>pmid=16126171 ------>page1=324 ------>fullAbstract=Hepatic fibrosis represents a process of healing and scarring in response to chronic liver injury. Interleukin-10 (IL-10) is a cytokine that downregulates the proinflammatory response and has a modulatory effect on hepatic fibrogenesis. The aim of this study was to investigate whether IL-10 gene therapy possesses anti-hepatic fibrogenesis in mice. Liver fibrosis was induced by long-term thioacetamide administration in mice. Human IL-10 expression plasmid was delivered via electroporation after liver fibrosis established. IL-10 gene therapy reversed hepatic fibrosis and prevented cell apoptosis in a thioacetamide-treated liver. RT-PCR revealed IL-10 gene therapy to reduce liver transforming growth factor-beta1, tumor necrosis factor-alpha, collagen alpha1, cell adhesion molecule, and tissue inhibitors of metalloproteinase mRNA upregulation. Following gene transfer, the activation of alpha-smooth muscle actin and cyclooxygenase-2 was significantly attenuated. In brief, IL-10 gene therapy might be an effective therapeutic reagent for liver fibrosis with potential future clinical applications. ------>tmu_sno=None ------>sno=15381 ------>authors2=Lee TH ------>authors3=Chou WY ------>authors4=Wu CL ------>authors5=Cho CL ------>authors6=Lu CN, Jawan B, and Wang CH ------>authors6_c= ------>authors=Hung KS ------>delete_flag=0 ------>SCI_JNo=None ------>authors2_c= ------>publish_area=0 ------>updateTitle=Interleukin-10 gene therapy reverses thioacetamide-induced liver fibrosis in mice. ------>language=2 ------>check_flag=None ------>submit_date=None ------>country=None ------>no=1 ------>patent_SDate=None ------>update_bywho=None ------>publish_year=2005 ------>submit_flag=None ------>publish_month=10 |