| Wang CH |
------>authors3_c= ------>paper_class1=1 ------>Impact_Factor=1.123 ------>paper_class3=2 ------>paper_class2=1 ------>vol=26 ------>confirm_bywho=None ------>insert_bywho=kshung ------>Jurnal_Rank=41.6 ------>authors4_c= ------>comm_author= ------>patent_EDate=None ------>authors5_c= ------>publish_day=1 ------>paper_class2Letter=None ------>page2=50 ------>medlineContent= ------>unit=000 ------>insert_date=20070501 ------>iam=3 ------>update_date=None ------>author=??? ------>change_event=1 ------>ISSN= ------>authors_c= ------>score=492 ------>journal_name=Acta Pharmacol Sin ------>paper_name=ntrathecal administration of roscovitine inhibits Cdk5 activity and attenuates formalin-induced nociceptive response in rats ------>confirm_date=None ------>tch_id=095047 ------>pmid=15659113 ------>page1=46 ------>fullAbstract=AIM: To investigate effects of the cyclin-dependent kinase5 (Cdk5) inhibitor roscovitine on formalin-induced nociceptive responses in rats. METHODS: The flinch response as a methood of pain threshold measurement and intrathecal injection techniques were used. Cdk5 and phosphorylation of its downstream target, DARPP-32 (dopamine- and cAMP-regulated phosphoprotein of M(r) 32 kDa), were investigated by Western blot analysis. RESULTS: Rats demonstrated a typical flinch response after formalin injection. Intrathecal roscovitine injections significantly suppressed the flinch response in a dose-dependent manner. Western blot analysis showed that phosphorylated DARPP-32 at Thr75 increased in concentration after formalin hyperalgesia, with this effect reduced by roscovitine administration. This antinociception was partially attenuated by administration of naloxone before the formalin test. CONCLUSION: DARPP-32 phosphorylation is involved in acute inflammatory pain response. Intrathecal roscovitine administration attenuates formalin-induced nociceptive responses and there is potential for further application. ------>tmu_sno=None ------>sno=15385 ------>authors2=Chou WY ------>authors3=Hung KS ------>authors4=Jawan B ------>authors5=Lu CN ------>authors6=Liu JK, Hung YP, Lee TH ------>authors6_c= ------>authors=Wang CH ------>delete_flag=0 ------>SCI_JNo=None ------>authors2_c= ------>publish_area=0 ------>updateTitle=Intrathecal administration of roscovitine inhibits Cdk5 activity and attenuates formalin-induced nociceptive response in rats. ------>language=2 ------>check_flag=None ------>submit_date=None ------>country=None ------>no=1 ------>patent_SDate=None ------>update_bywho=None ------>publish_year=2005 ------>submit_flag=None ------>publish_month=1 |