| Wong KL |
------>authors3_c= ------>paper_class1=1 ------>Impact_Factor=1.375 ------>paper_class3=2 ------>paper_class2=1 ------>vol=76 ------>confirm_bywho=shiemin ------>insert_bywho=hippy ------>Jurnal_Rank=65.3 ------>authors4_c= ------>comm_author= ------>patent_EDate=None ------>authors5_c= ------>publish_day=9 ------>paper_class2Letter=None ------>page2=169 ------>medlineContent= ------>unit=E0100 ------>insert_date=20070502 ------>iam=7 ------>update_date=None ------>author=??? ------>change_event=4 ------>ISSN= ------>authors_c= ------>score=500 ------>journal_name=Pharmacology ------>paper_name=Antiproliferative effect of isosteviol on angiotensin-II-treated rat aortic smooth muscle cells ------>confirm_date=20070504 ------>tch_id=093148 ------>pmid=16479148 ------>page1=163 ------>fullAbstract=Isosteviol is a derivative of stevioside, a constituent of Stevia rebaudiana, which is commonly used as a noncaloric sugar substitute in Japan and Brazil. The aims of this study were to examine whether isosteviol alters angiotensin-II-induced cell proliferation in rat aortic smooth muscle cells. Cultured rat aortic smooth muscle cells were preincubated with isosteviol, then stimulated with angiotensin II, after which [(3)H]thymidine incorporation and endothelin-1 secretion were examined. Isosteviol (1-100 micromol/l) inhibits angiotensin-II-induced DNA synthesis and endothelin-1 secretion. Measurements of 2~7~-dichlorofluorescin diacetate, a redox-sensitive fluorescent dye, showed an isosteviol-mediated inhibition of intracellular reactive oxygen species generated by the effects of angiotensin II. The inductive properties of angiotensin II on extracellular signal-regulated kinase (ERK) phosphorylation were found reversed with isosteviol and antioxidants such as N-acetylcysteine. In summary, we speculate that isosteviol inhibits angiotensin-II-induced cell proliferation and endothelin-1 secretion via attenuation of reactive oxygen species generation. Thus, this study provides important insights that may contribute to the effects of isosteviol on the cardiovascular system. ------>tmu_sno=None ------>sno=15422 ------>authors2=Lin JW ------>authors3=Liu JC ------>authors4=Yang HY ------>authors5=Kao PF ------>authors6=Chen CH, Loh SH, Chiu WT, Cheng TH, Lin JG, Hong H ------>authors6_c= ------>authors=Wong KL ------>delete_flag=0 ------>SCI_JNo=None ------>authors2_c= ------>publish_area=0 ------>updateTitle=Antiproliferative effect of isosteviol on angiotensin-II-treated rat aortic smooth muscle cells. ------>language=2 ------>check_flag=None ------>submit_date=None ------>country=None ------>no=4 ------>patent_SDate=None ------>update_bywho=None ------>publish_year=2006 ------>submit_flag=None ------>publish_month=2 |