| McCarty KM |
------>authors3_c= ------>paper_class1=1 ------>Impact_Factor=5.342 ------>paper_class3=2 ------>paper_class2=1 ------>vol=115 ------>confirm_bywho=hychiou ------>insert_bywho=ymhsueh ------>Jurnal_Rank=0.7 ------>authors4_c= ------>comm_author= ------>patent_EDate=None ------>authors5_c= ------>publish_day=1 ------>paper_class2Letter=None ------>page2=345 ------>medlineContent= ------>unit=E0108 ------>insert_date=20070502 ------>iam=7 ------>update_date=None ------>author=??? ------>change_event=4 ------>ISSN= ------>authors_c= ------>score=500 ------>journal_name=Environ Health Perspect ------>paper_name=Arsenic methylation, GSTT1, GSTM1, GSTP1 polymorphisms, and skin lesions ------>confirm_date=20070506 ------>tch_id=073001 ------>pmid=17431481 ------>page1=341 ------>fullAbstract=OBJECTIVE: We investigated whether primary and secondary arsenic methylation ratios were associated with skin lesions and whether GSTT1, GSTP1, and GSTM1 polymorphisms modify these relationships. METHODS: A case-control study of 600 cases and 600 controls that were frequency matched on age and sex was conducted in Pabna, Bangladesh, in 2001-2002. Individual well water, urine, and blood samples were collected. Water arsenic concentration was determined using inductively coupled plasma mass spectrometry (ICP-MS). Urinary arsenic speciation was determined using high performance liquid chromatography hydride with generator atomic absorption spectrometry and ICP-MS. Genotyping was conducted using multiplex polymerase chain reaction and TaqMan. RESULTS: A 10-fold increase in primary methylation ratio [monomethylarsonic acid (MMA)/(arsenite + arsenate] was associated with a 1.50-fold increased risk of skin lesions (multivariate odds ratio = 1.50; 95% confidence interval, 1.00-2.26). We observed significant interaction on the multiplicative scale between GSTT1 wildtype and secondary methylation ratio [dimethylarsinic acid/MMA; likelihood ratio test (LRT), p = 0.01]. No significant interactions were observed for GSTM1 or GSTP1 or for primary methylation ratios. CONCLUSION: Our findings suggest that increasing primary methylation ratios are associated with an increase in risk of arsenic-related skin lesions. The interaction between GSTT1 wildtype and secondary methylation ratio modifies risk of skin lesions among arsenic-exposed individuals. ------>tmu_sno=None ------>sno=15444 ------>authors2=Chen YC ------>authors3=Quamruzzaman Q ------>authors4=Rahman M ------>authors5=Mahiuddin G ------>authors6=Hsueh YM, Su L, Smith T, Ryan L, Christiani DC ------>authors6_c= ------>authors=McCarty KM ------>delete_flag=0 ------>SCI_JNo=None ------>authors2_c= ------>publish_area=0 ------>updateTitle=Arsenic methylation, GSTT1, GSTM1, GSTP1 polymorphisms, and skin lesions. ------>language=2 ------>check_flag=None ------>submit_date=None ------>country=None ------>no=3 ------>patent_SDate=None ------>update_bywho=None ------>publish_year=2007 ------>submit_flag=None ------>publish_month=1 |