| Wu JF |
------>authors3_c= ------>paper_class1=1 ------>Impact_Factor=2.491 ------>paper_class3=2 ------>paper_class2=1 ------>vol= ------>confirm_bywho=shiemin ------>insert_bywho=eyshen ------>Jurnal_Rank=46.1 ------>authors4_c= ------>comm_author= ------>patent_EDate=None ------>authors5_c= ------>publish_day=3 ------>paper_class2Letter=None ------>page2=124 ------>medlineContent= ------>unit=E0113 ------>insert_date=20070503 ------>iam=5 ------>update_date=None ------>author=??? ------>change_event=4 ------>ISSN=0896-8411 ------>authors_c= ------>score=500 ------>journal_name=Journal of Autoimmunity ------>paper_name=Antinucleosome antibodies correlate with the disease severity in children with systemic lupus erythematosus ------>confirm_date=20070505 ------>tch_id=079020 ------>pmid=16919912 ------>page1=119 ------>fullAbstract=We compared the serum levels of antinucleosome antibodies (anti-NCS Abs) in thirty pediatric systemic lupus erythematosus (SLE) patients by using enzyme-linked immunosorbent assay (ELISA) to 29 adult SLE patients, 30 healthy controls, 21 juvenile idiopathic arthritis (JIA) and 23 Henoch-Schonlein purpura (HSP) patients as autoimmune disease controls. The mean anti-NCS Ab titer in the pediatric SLE patients was 1552.7+/-1842.2 U/ml, higher than those of adult SLE patients (194.3+/-402.7 U/ml), normal controls (9.5+/-5.7 U/ml) and disease controls (JIA: 7.7+/-4.0 U/ml, HSP: 5.7+/-4.4 U/ml) (p<0.05). The prevalence of both anti-NCS Ab (90%) and anti-ds DNA Ab (76.7%) in pediatric SLE patients were higher (p<0.05) than that of adult SLE patients (58.6% and 48.3%). A positive correlation was demonstrated between anti-NCS Ab and anti-dsDNA Ab as well as the SLEDAI scores in pediatric and adult patients (p<0.05). The inverse correlation of anti-NCS Ab levels with C3 was observed in both pediatric and adult SLE patients (pediatrics, r=-0.61, p=0.0003; adult, r=-0.44, p=0.02). Our data suggested that in pediatric SLE patients, anti-NCS Ab could be as good a marker for SLE diagnosis and disease activity assessment as in adult SLE patients. ------>tmu_sno=None ------>sno=15461 ------>authors2=Yang YH ------>authors3=Wang LC ------>authors4=Lee JH ------>authors5=Shen EY ------>authors6=,Chiang BL ------>authors6_c= ------>authors=Wu JF ------>delete_flag=0 ------>SCI_JNo=None ------>authors2_c= ------>publish_area=0 ------>updateTitle=Antinucleosome antibodies correlate with the disease severity in children with systemic lupus erythematosus. ------>language=1 ------>check_flag=None ------>submit_date=None ------>country=None ------>no=27 ------>patent_SDate=None ------>update_bywho=None ------>publish_year=2006 ------>submit_flag=None ------>publish_month=7 |