Taipei Medical University

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Chen CH
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------>journal_name=Eur J Pharmacol
------>paper_name=The protective effect of prostacyclin on adriamycin-induced apoptosis in rat renal tubular cells
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------>fullAbstract=Adriamycin-induced nephrosis in rats is a commonly used experimental model for pharmacological studies of human chronic renal diseases. Adriamycin-induced apoptosis of renal tubular cells has been reported in adriamycin-treated rats. In addition, prostacyclin (PGI(2)) is known to have various protective effects on many kinds of cells. To investigate the protective effect of PGI(2) on cells undergoing adriamycin-induced apoptosis, this study selectively augmented PGI(2) production via adenovirus-mediated transfer of genes for cyclooxygenase-1 (COX-1) and prostacyclin synthase (PGIS) (two key enzymes of PGI(2) synthesis) to renal tubular cells. This PGI(2) overexpression protected rat renal tubular cells from adriamycin-induced apoptosis. Ad-COX-1/PGIS transfection was found to reduce the adriamycin-stimulated activities of caspase-3 and caspase-9, inhibit adriamycin-induced release of cytochrome c, elevate the expression of Bcl-x(L), and suppress the activation and translocation of nuclear factor-kappaB (NF-kappaB) in adriamycin-treated renal tubular cells. Our results reveal that selective augmentation of PGI(2) production can protect rat renal tubular cells from adriamycin-induced apoptosis via the NF-kappaB signaling pathway. This implies the therapeutic potential of combined COX-1 and PGIS gene transfer in gene therapy for chronic renal diseases.
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------>authors2=Lin H
------>authors3=Hsu YH
------>authors4=Sue YM
------>authors5=Cheng TH
------>authors6=Chan P, Chen TH
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------>authors=Chen CH
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------>updateTitle=The protective effect of prostacyclin on adriamycin-induced apoptosis in rat renal tubular cells.
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------>no=1-3
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------>publish_year=2006
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A B C D E F G H I J K L M N O P Q R S T U V W X Y Z