Sue YM |
------>authors3_c= ------>paper_class1=1 ------>Impact_Factor=1.023 ------>paper_class3=2 ------>paper_class2=1 ------>vol=9 ------>confirm_bywho=ncchang ------>insert_bywho=sueym ------>Jurnal_Rank=74.5 ------>authors4_c= ------>comm_author= ------>patent_EDate=None ------>authors5_c= ------>publish_day=1 ------>paper_class2Letter=None ------>page2=18 ------>medlineContent= ------>unit=E0109 ------>insert_date=20070504 ------>iam=1 ------>update_date=None ------>author=??? ------>change_event=4 ------>ISSN=1320-5358 ------>authors_c= ------>score=500 ------>journal_name=Nephrology ------>paper_name=Clinical features of thin basement membrane disease and associated glomerulopathies. ------>confirm_date=20080312 ------>tch_id=093141 ------>pmid=14996302 ------>page1=14 ------>fullAbstract=BACKGROUND: Thin basement membrane disease (TBMD) occurs in 5-11% of renal biopsy series, and can be associated with other glomerulopathies (GNs). Data on the prevalence, clinical features, and prognosis of TBMD with other GNs are limited. METHODS AND RESULTS: From June 1990 to May 2001, findings from 658 native kidney biopsies were retrospectively studied. The overall prevalence of TBMD was 7.9% (52 of 658). The mean glomerular basement membrane (GBM) thickness was 206 +/- 30 nm. Clinicopathological features were compared for patients with TBMD only (n = 14) and in those with TBMD and GN (n = 38). Focal segmental glomerulosclerosis, mesangial proliferative GN, and minimal change disease were the most common GNs associated with TBMD. After a mean follow-up period of 44.9 +/- 42.5 months, the group who only had TBMD revealed a relatively benign disease with microscopic haematuria and trivial proteinuria, a low prevalence of hypertension, and no renal progression. In the group who had both TBMD and GN, heavy proteinuria (6.1 +/- 5.2 g/day), hypoalbuminaemia (26 +/- 12 g/L) and renal insufficiency (76 +/- 25 mL/min) might develop. CONCLUSION: We suggested that the TBMD is a developmental abnormality of little or no significance and that it is the underlying associated GN rather than TBMD, which has the relevance to the outcome of renal disease. ------>tmu_sno=None ------>sno=15515 ------>authors2=Huang JJ ------>authors3=Hsieh RY ------>authors4=Chen FF ------>authors5= ------>authors6= ------>authors6_c= ------>authors=Sue YM ------>delete_flag=0 ------>SCI_JNo=None ------>authors2_c= ------>publish_area=0 ------>updateTitle=Clinical features of thin basement membrane disease and associated glomerulopathies. ------>language=2 ------>check_flag=None ------>submit_date=None ------>country=None ------>no=1 ------>patent_SDate=None ------>update_bywho=None ------>publish_year=2004 ------>submit_flag=None ------>publish_month=2 |