Taipei Medical University

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Huang ZS
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------>journal_name=J. Biol. Chem.
------>paper_name=Selective strand annealing and selective strand exchange promoted by the N-terminal domain of hepatitis delta antigen.
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------>fullAbstract=We have previously shown that the N-terminal domain of hepatitis delta virus (NdAg) has an RNA chaperone activity in vitro (Huang, Z. S., and Wu, H. N. (1998) J. Biol. Chem. 273, 26455-26461). Here we investigate further the basis of the stimulatory effect of NdAg on RNA structural rearrangement: mainly the formation and breakage of base pairs. Duplex dissociation, strand annealing, and exchange of complementary RNA oligonucleotides; the hybridization of yeast U4 and U6 small nuclear RNAs and of hammerhead ribozymes and cognate substrates; and the cis-cleavage reaction of hepatitis delta ribozymes were used to determine directly the role of NdAg in RNA-mediated processes. The results showed that NdAg could accelerate the annealing of complementary sequences in a selective fashion and promote strand exchange for the formation of a more extended duplex. These activities would prohibit NdAg from modifying the structure of a stable RNA, but allow NdAg to facilitate a trans-acting hammerhead ribozyme to find a more extensively matched target in cognate substrate. These and other results suggest that hepatitis delta antigen may have a biological role as an RNA chaperone, modulating the folding of viral RNA for replication and transcription.
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------>authors2=Su WH
------>authors3=Wang JL
------>authors4=Wu HN
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------>authors=Huang ZS
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------>updateTitle=Selective strand annealing and selective strand exchange promoted by the N-terminal domain of hepatitis delta antigen.
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------>no=8
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------>publish_year=2003
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A B C D E F G H I J K L M N O P Q R S T U V W X Y Z