| Lin JH |
------>authors3_c= ------>paper_class1=1 ------>Impact_Factor=5.178 ------>paper_class3=2 ------>paper_class2=1 ------>vol=81 ------>confirm_bywho=jschu ------>insert_bywho=jschu ------>Jurnal_Rank=17.4 ------>authors4_c= ------>comm_author= ------>patent_EDate=None ------>authors5_c= ------>publish_day=1 ------>paper_class2Letter=None ------>page2=5713 ------>medlineContent= ------>unit=E0102 ------>insert_date=20070904 ------>iam=3 ------>update_date=None ------>author=??? ------>change_event=4 ------>ISSN= ------>authors_c= ------>score=500 ------>journal_name=Journal of Virology ------>paper_name=Dysregulation of HER2/HER3 signaling axis in Epstein-Barr virus-infected breast carcinoma cells ------>confirm_date=20080430 ------>tch_id=087008 ------>pmid=17376931 ------>page1=5705 ------>fullAbstract=The role of Epstein-Barr virus (EBV) in the pathogenesis of breast cancer has been of long-standing interest to the field. Breast epithelial cells can be infected by EBV through direct contact with EBV-bearing lymphoblastoid cells, and EBV infection has recently been shown to confer breast cancer cells an increased resistance to chemotherapeutic drugs. In this study, we established EBV-infected breast cancer MCF7 and BT474 cells and demonstrated that EBV infection promotes tumorigenic activity of breast cancer cells. Firstly, we showed that the EBV-infected MCF7-A and BT474-A cells exhibited increased anchorage-independent growth in soft agar. The increased colony formation capacity in soft agar was associated with increased expression and activation of HER2/HER3 signaling cascades, as evidenced by the findings that the treatment of HER2 antibody trastuzumab (Herceptin), phosphatidylinositol 3-kinase inhibitor, or MEK inhibitor completely abolished the tumorigenic capacity. In the EBV-infected breast cancer cells, the expression of EBV latency genes including EBNA1, EBER1, and BARF0 was detected. We next showed that BARF0 alone was sufficient to efficiently up-regulate HER2/HER3 expression and promoted tumorigenic activity in MCF7 and BT474 cells by the use of both overexpression and small interfering RNA knock-down. Collectively, we demonstrated that EBV-encoded BARF0 promotes the tumorigenic activity of breast cancer cells through activation of HER2/HER3 signaling cascades. ------>tmu_sno=None ------>sno=15971 ------>authors2=Tsai CH ------>authors3=Chu JS ------>authors4=Chen JY ------>authors5=Takada K ------>authors6=Shew JY ------>authors6_c= ------>authors=Lin JH ------>delete_flag=0 ------>SCI_JNo=None ------>authors2_c= ------>publish_area=0 ------>updateTitle=Dysregulation of HER2/HER3 signaling axis in Epstein-Barr virus-infected breast carcinoma cells. ------>language=2 ------>check_flag=None ------>submit_date=None ------>country=None ------>no=11 ------>patent_SDate=None ------>update_bywho=None ------>publish_year=2007 ------>submit_flag=None ------>publish_month=6 |