Taipei Medical University

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Liao, H.J.
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------>journal_name=J Agric Food Chem
------>paper_name=Inhibitory effect of caffeic acid phenethyl ester on angiogenesis, tumor invasion, and metastasis
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------>fullAbstract=Caffeic acid phenethyl ester (CAPE) derived from honeybee propolis has been used as a folk medicine and has several proven biological activities. The present study investigated the effect of CAPE on angiogenesis, tumor invasion, and metastasis. A cytotoxicity assay of CAPE in CT26 colon adenocarcinoma cells showed a dose-dependent decrease in cell viability but no significant influence on the growth of human umbilical vein epithelial cells (HUVEC). A low concentration of CAPE (1.5 microg/mL) inhibited 52.7% of capillary-like tube formation in HUVEC culture on Matrigel. CAPE (6 microg/mL)-treated CT26 cells showed not only inhibited cell invasion by 47.8% but also decreased expression of matrix metalloproteinase (MMP)-2 and -9. Vascular endothelial growth factor (VEGF) production from CT26 cells was also inhibited by treatment with CAPE (6 microg/mL). Intraperitoneal injection of CAPE (10 mg/kg/day) in BALB/c mice reduced the pulmonary metastatic capacity of CT26 cells accompanied with a decreased plasma VEGF level. CAPE treatment also prolonged the survival of mice implanted with CT26 cells. These results indicate that CAPE has potential as an antimetastatic agent.
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------>authors2=Chen, Y.J
------>authors3=Liu, J.J
------>authors4=Hsu, M.L.
------>authors5=Shieh, H.J
------>authors6=Shieh, C.J., Shiao, M.S.
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------>authors=Liao, H.J.
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------>updateTitle=Inhibitory effect of caffeic acid phenethyl ester on angiogenesis, tumor invasion, and metastasis.
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------>publish_year=2003
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A B C D E F G H I J K L M N O P Q R S T U V W X Y Z