Liao, H.J. |
------>authors3_c= ------>paper_class1=1 ------>Impact_Factor=2.507 ------>paper_class3=2 ------>paper_class2=1 ------>vol=51 ------>confirm_bywho=leehorng ------>insert_bywho=jjliu_96 ------>Jurnal_Rank=10.2 ------>authors4_c= ------>comm_author= ------>patent_EDate=None ------>authors5_c= ------>publish_day=1 ------>paper_class2Letter=None ------>page2=7912 ------>medlineContent= ------>unit=000 ------>insert_date=20070929 ------>iam=3 ------>update_date=None ------>author=??? ------>change_event=4 ------>ISSN= ------>authors_c= ------>score=500 ------>journal_name=J Agric Food Chem ------>paper_name=Inhibitory effect of caffeic acid phenethyl ester on angiogenesis, tumor invasion, and metastasis ------>confirm_date=20080418 ------>tch_id=096027 ------>pmid=14690372 ------>page1=7907 ------>fullAbstract=Caffeic acid phenethyl ester (CAPE) derived from honeybee propolis has been used as a folk medicine and has several proven biological activities. The present study investigated the effect of CAPE on angiogenesis, tumor invasion, and metastasis. A cytotoxicity assay of CAPE in CT26 colon adenocarcinoma cells showed a dose-dependent decrease in cell viability but no significant influence on the growth of human umbilical vein epithelial cells (HUVEC). A low concentration of CAPE (1.5 microg/mL) inhibited 52.7% of capillary-like tube formation in HUVEC culture on Matrigel. CAPE (6 microg/mL)-treated CT26 cells showed not only inhibited cell invasion by 47.8% but also decreased expression of matrix metalloproteinase (MMP)-2 and -9. Vascular endothelial growth factor (VEGF) production from CT26 cells was also inhibited by treatment with CAPE (6 microg/mL). Intraperitoneal injection of CAPE (10 mg/kg/day) in BALB/c mice reduced the pulmonary metastatic capacity of CT26 cells accompanied with a decreased plasma VEGF level. CAPE treatment also prolonged the survival of mice implanted with CT26 cells. These results indicate that CAPE has potential as an antimetastatic agent. ------>tmu_sno=None ------>sno=16007 ------>authors2=Chen, Y.J ------>authors3=Liu, J.J ------>authors4=Hsu, M.L. ------>authors5=Shieh, H.J ------>authors6=Shieh, C.J., Shiao, M.S. ------>authors6_c= ------>authors=Liao, H.J. ------>delete_flag=0 ------>SCI_JNo=None ------>authors2_c= ------>publish_area=0 ------>updateTitle=Inhibitory effect of caffeic acid phenethyl ester on angiogenesis, tumor invasion, and metastasis. ------>language=2 ------>check_flag=None ------>submit_date=None ------>country=None ------>no= ------>patent_SDate=None ------>update_bywho=None ------>publish_year=2003 ------>submit_flag=None ------>publish_month=1 |