Taipei Medical University

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Chen CM
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------>journal_name=pediatric research
------>paper_name=Up-regulation of Connective Tissue Growth Factor in Hyperoxia-Induced Lung Fibrosis
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------>fullAbstract=Pulmonary oxygen toxicity plays an important role in the lung injury process that leads to the development of bronchopulmonary dysplasia. Connective tissue growth factor (CTGF) is a fibroblast mitogen and promoter of collagen deposition. We investigated the effects of postnatal hyperoxia on lung collagen and CTGF expression in rats. Rat pups were exposed to 7 d of >95% O2 and a further 3 wk of 60% O2. CTGF mRNA and protein expression increased after hyperoxia treatment, and the values were significantly higher in hyperoxia-exposed rats on postnatal d 7 and 14. Lung collagen levels increased as rats aged, and the values were comparable between room air-exposed and hyperoxia-exposed rats on postnatal d 7 and 14 and were significantly higher in hyperoxia-exposed rats on postnatal d 21 and 28. Increases in CTGF mRNA and protein expressions preceded the onset of increased lung collagen. These data demonstrate that CTGF is up-regulated at time points preceding the fibrotic phase of the lung injury adding credence to the hypothesis that CTGF seems to be involved in the pathogenesis of hyperoxia-induced lung fibrosis and an anti-CTGF strategy might attenuate hyperoxia-induced lung fibrosis.
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------>authors2=Wang LF
------>authors3=Chou HC
------>authors4=Lang YD
------>authors5=Lai YP
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------>authors=Chen CM
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------>updateTitle=Up-regulation of connective tissue growth factor in hyperoxia-induced lung fibrosis.
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------>publish_year=2007
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A B C D E F G H I J K L M N O P Q R S T U V W X Y Z