Chen CM |
------>authors3_c= ------>paper_class1=1 ------>Impact_Factor=2.619 ------>paper_class3=2 ------>paper_class2=1 ------>vol=62 ------>confirm_bywho=thfong ------>insert_bywho=chou0217 ------>Jurnal_Rank=13.5 ------>authors4_c= ------>comm_author= ------>patent_EDate=None ------>authors5_c= ------>publish_day=1 ------>paper_class2Letter=None ------>page2=133 ------>medlineContent= ------>unit=E0107 ------>insert_date=20071018 ------>iam=3 ------>update_date=None ------>author=??? ------>change_event=4 ------>ISSN= ------>authors_c= ------>score=500 ------>journal_name=pediatric research ------>paper_name=Up-regulation of Connective Tissue Growth Factor in Hyperoxia-Induced Lung Fibrosis ------>confirm_date=20071128 ------>tch_id=080001 ------>pmid=17597657 ------>page1=128 ------>fullAbstract=Pulmonary oxygen toxicity plays an important role in the lung injury process that leads to the development of bronchopulmonary dysplasia. Connective tissue growth factor (CTGF) is a fibroblast mitogen and promoter of collagen deposition. We investigated the effects of postnatal hyperoxia on lung collagen and CTGF expression in rats. Rat pups were exposed to 7 d of >95% O2 and a further 3 wk of 60% O2. CTGF mRNA and protein expression increased after hyperoxia treatment, and the values were significantly higher in hyperoxia-exposed rats on postnatal d 7 and 14. Lung collagen levels increased as rats aged, and the values were comparable between room air-exposed and hyperoxia-exposed rats on postnatal d 7 and 14 and were significantly higher in hyperoxia-exposed rats on postnatal d 21 and 28. Increases in CTGF mRNA and protein expressions preceded the onset of increased lung collagen. These data demonstrate that CTGF is up-regulated at time points preceding the fibrotic phase of the lung injury adding credence to the hypothesis that CTGF seems to be involved in the pathogenesis of hyperoxia-induced lung fibrosis and an anti-CTGF strategy might attenuate hyperoxia-induced lung fibrosis. ------>tmu_sno=None ------>sno=16094 ------>authors2=Wang LF ------>authors3=Chou HC ------>authors4=Lang YD ------>authors5=Lai YP ------>authors6= ------>authors6_c= ------>authors=Chen CM ------>delete_flag=0 ------>SCI_JNo=None ------>authors2_c= ------>publish_area=0 ------>updateTitle=Up-regulation of connective tissue growth factor in hyperoxia-induced lung fibrosis. ------>language=2 ------>check_flag=None ------>submit_date=None ------>country=None ------>no=2 ------>patent_SDate=None ------>update_bywho=None ------>publish_year=2007 ------>submit_flag=None ------>publish_month=1 |