| Huang SY |
------>authors3_c= ------>paper_class1=1 ------>Impact_Factor=3.710 ------>paper_class3=2 ------>paper_class2=1 ------>vol=42 ------>confirm_bywho=sihuang ------>insert_bywho=sihuang ------>Jurnal_Rank=25.5 ------>authors4_c= ------>comm_author= ------>patent_EDate=None ------>authors5_c= ------>publish_day=1 ------>paper_class2Letter=None ------>page2=63 ------>medlineContent= ------>unit=J0400 ------>insert_date=20071109 ------>iam=1 ------>update_date=None ------>author=??? ------>change_event=4 ------>ISSN= ------>authors_c= ------>score=500 ------>journal_name=Journal of Psychiatric Research ------>paper_name=Omega-3 fatty acids on the forced-swimming test ------>confirm_date=20080720 ------>tch_id=085004 ------>pmid=17070845 ------>page1=58 ------>fullAbstract=OBJECTIVES: Based on the findings of epidemiological data and recent clinical trials, omega-3 fatty acids seem to have a preventive and therapeutic effect on depression. METHOD: We examined the effect of omega-3 fatty acids on the forced-swimming test (FST) in two groups of Sprague-Dawley rats after a six-week treatment with two different diets. Behavioral responses were observed and recorded during the 5-min test. The fatty acid composition from the whole brain tissue and the RBC membrane of the rats were analyzed. RESULTS: Comparing to control diet, omega-3 fatty acid diet significantly decreased the immobility time (218 +/- 16 vs. 183 +/- 19s, p = 0.001) and increased behaviors of swimming (32 +/- 7 vs. 45 +/- 9s, p = 0.012) and climbing (50 +/- 10 vs. 73 +/- 14s, p = 0.011) during the FST. The group in omega-3 fatty acid diet had higher levels of docosahexaenoic acid (DHA, 50% increase) and alpha-linolenic acid (ALA, 63% increase) in the brain, and of eicosapentaenoic acid (EPA, 27% increase) in the peripheral RBC membrane. The level of brain DHA is negatively correlated to the immobility time (r = -0.654, p = 0.006) and is positively correlated to the swimming time (r = 0.69, p = 0.003). CONCLUSION: The result shows that omega-3 fatty acids have a beneficial effect on preventing the development of depression-like behaviors in rats with the FST. ------>tmu_sno=None ------>sno=16153 ------>authors2=Yang HT ------>authors3=Chiu CC ------>authors4=Pariante CM ------>authors5=Su KP ------>authors6= ------>authors6_c= ------>authors=Huang SY ------>delete_flag=0 ------>SCI_JNo=None ------>authors2_c= ------>publish_area=0 ------>updateTitle=Omega-3 fatty acids on the forced-swimming test. ------>language=2 ------>check_flag=None ------>submit_date=None ------>country=None ------>no=1 ------>patent_SDate=None ------>update_bywho=None ------>publish_year=2008 ------>submit_flag=None ------>publish_month=1 |